WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation

Human WNT10A mutations are associated with developmental tooth abnormalities and adolescent onset of a broad range of ectodermal defects. Here we show that β-catenin pathway activity and adult epithelial progenitor proliferation are reduced in the absence of WNT10A, and identify Wnt-active self-rene...

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Detalles Bibliográficos
Autores principales: Xu, Mingang, Horrell, Jeremy, Snitow, Melinda, Cui, Jiawei, Gochnauer, Heather, Syrett, Camille M., Kallish, Staci, Seykora, John T., Liu, Fei, Gaillard, Dany, Katz, Jonathan P., Kaestner, Klaus H., Levin, Brooke, Mansfield, Corinne, Douglas, Jennifer E., Cowart, Beverly J., Tordoff, Michael, Liu, Fang, Zhu, Xuming, Barlow, Linda A., Rubin, Adam I., McGrath, John A., Morrisey, Edward E., Chu, Emily Y., Millar, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467248/
https://www.ncbi.nlm.nih.gov/pubmed/28589954
http://dx.doi.org/10.1038/ncomms15397

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