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Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity
The aim of the study was to assess the impact of regular professional sports activity on the endothelial and platelet function in young men. The studied group were 79 young men (18–40 y, 25 athletes and 54 without any regular physical activity). The nitric oxide (NO) metabolic pathway intermediates,...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467294/ https://www.ncbi.nlm.nih.gov/pubmed/28630872 http://dx.doi.org/10.1155/2017/8715909 |
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author | Podgórska, Katarzyna Derkacz, Arkadiusz Szahidewicz-Krupska, Ewa Jasiczek, Jakub Dobrowolski, Piotr Radziwon-Balicka, Aneta Skomro, Robert Szuba, Andrzej Mazur, Grzegorz Doroszko, Adrian |
author_facet | Podgórska, Katarzyna Derkacz, Arkadiusz Szahidewicz-Krupska, Ewa Jasiczek, Jakub Dobrowolski, Piotr Radziwon-Balicka, Aneta Skomro, Robert Szuba, Andrzej Mazur, Grzegorz Doroszko, Adrian |
author_sort | Podgórska, Katarzyna |
collection | PubMed |
description | The aim of the study was to assess the impact of regular professional sports activity on the endothelial and platelet function in young men. The studied group were 79 young men (18–40 y, 25 athletes and 54 without any regular physical activity). The nitric oxide (NO) metabolic pathway intermediates, oxidative stress markers, mediators of inflammation, and platelet aggregation were measured. Flow mediated dilation (FMD) was studied before and after intravenous 16,0 g L-arginine infusion, which was repeated after oral administration of acetylsalicylic acid (ASA-75 mg/day) for 4 days. Both groups had similar demographic characteristics. In the athletes, there was significantly higher hsCRP level, better serum lipid profile, and lower pulse pressure. Greater baseline FMD in athletes and in response to L-arginine disappeared following ASA treatment. There were no differences in the levels of the NO pathway metabolites. The control group was characterized by higher PAI-1 following ASA treatment and sICAM-1 both at baseline and after ASA, but no differences in MDA and 6-keto-PGF-1 alpha and platelet aggregation were noted. Regular professional physical activity modulates endothelial but not platelet function and may thus exert an effect on overall cardiovascular risk. |
format | Online Article Text |
id | pubmed-5467294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54672942017-06-19 Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity Podgórska, Katarzyna Derkacz, Arkadiusz Szahidewicz-Krupska, Ewa Jasiczek, Jakub Dobrowolski, Piotr Radziwon-Balicka, Aneta Skomro, Robert Szuba, Andrzej Mazur, Grzegorz Doroszko, Adrian Biomed Res Int Research Article The aim of the study was to assess the impact of regular professional sports activity on the endothelial and platelet function in young men. The studied group were 79 young men (18–40 y, 25 athletes and 54 without any regular physical activity). The nitric oxide (NO) metabolic pathway intermediates, oxidative stress markers, mediators of inflammation, and platelet aggregation were measured. Flow mediated dilation (FMD) was studied before and after intravenous 16,0 g L-arginine infusion, which was repeated after oral administration of acetylsalicylic acid (ASA-75 mg/day) for 4 days. Both groups had similar demographic characteristics. In the athletes, there was significantly higher hsCRP level, better serum lipid profile, and lower pulse pressure. Greater baseline FMD in athletes and in response to L-arginine disappeared following ASA treatment. There were no differences in the levels of the NO pathway metabolites. The control group was characterized by higher PAI-1 following ASA treatment and sICAM-1 both at baseline and after ASA, but no differences in MDA and 6-keto-PGF-1 alpha and platelet aggregation were noted. Regular professional physical activity modulates endothelial but not platelet function and may thus exert an effect on overall cardiovascular risk. Hindawi 2017 2017-05-29 /pmc/articles/PMC5467294/ /pubmed/28630872 http://dx.doi.org/10.1155/2017/8715909 Text en Copyright © 2017 Katarzyna Podgórska et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Podgórska, Katarzyna Derkacz, Arkadiusz Szahidewicz-Krupska, Ewa Jasiczek, Jakub Dobrowolski, Piotr Radziwon-Balicka, Aneta Skomro, Robert Szuba, Andrzej Mazur, Grzegorz Doroszko, Adrian Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity |
title | Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity |
title_full | Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity |
title_fullStr | Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity |
title_full_unstemmed | Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity |
title_short | Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity |
title_sort | effect of regular aerobic activity in young healthy athletes on profile of endothelial function and platelet activity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467294/ https://www.ncbi.nlm.nih.gov/pubmed/28630872 http://dx.doi.org/10.1155/2017/8715909 |
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