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Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity

The aim of the study was to assess the impact of regular professional sports activity on the endothelial and platelet function in young men. The studied group were 79 young men (18–40 y, 25 athletes and 54 without any regular physical activity). The nitric oxide (NO) metabolic pathway intermediates,...

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Autores principales: Podgórska, Katarzyna, Derkacz, Arkadiusz, Szahidewicz-Krupska, Ewa, Jasiczek, Jakub, Dobrowolski, Piotr, Radziwon-Balicka, Aneta, Skomro, Robert, Szuba, Andrzej, Mazur, Grzegorz, Doroszko, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467294/
https://www.ncbi.nlm.nih.gov/pubmed/28630872
http://dx.doi.org/10.1155/2017/8715909
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author Podgórska, Katarzyna
Derkacz, Arkadiusz
Szahidewicz-Krupska, Ewa
Jasiczek, Jakub
Dobrowolski, Piotr
Radziwon-Balicka, Aneta
Skomro, Robert
Szuba, Andrzej
Mazur, Grzegorz
Doroszko, Adrian
author_facet Podgórska, Katarzyna
Derkacz, Arkadiusz
Szahidewicz-Krupska, Ewa
Jasiczek, Jakub
Dobrowolski, Piotr
Radziwon-Balicka, Aneta
Skomro, Robert
Szuba, Andrzej
Mazur, Grzegorz
Doroszko, Adrian
author_sort Podgórska, Katarzyna
collection PubMed
description The aim of the study was to assess the impact of regular professional sports activity on the endothelial and platelet function in young men. The studied group were 79 young men (18–40 y, 25 athletes and 54 without any regular physical activity). The nitric oxide (NO) metabolic pathway intermediates, oxidative stress markers, mediators of inflammation, and platelet aggregation were measured. Flow mediated dilation (FMD) was studied before and after intravenous 16,0 g L-arginine infusion, which was repeated after oral administration of acetylsalicylic acid (ASA-75 mg/day) for 4 days. Both groups had similar demographic characteristics. In the athletes, there was significantly higher hsCRP level, better serum lipid profile, and lower pulse pressure. Greater baseline FMD in athletes and in response to L-arginine disappeared following ASA treatment. There were no differences in the levels of the NO pathway metabolites. The control group was characterized by higher PAI-1 following ASA treatment and sICAM-1 both at baseline and after ASA, but no differences in MDA and 6-keto-PGF-1 alpha and platelet aggregation were noted. Regular professional physical activity modulates endothelial but not platelet function and may thus exert an effect on overall cardiovascular risk.
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spelling pubmed-54672942017-06-19 Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity Podgórska, Katarzyna Derkacz, Arkadiusz Szahidewicz-Krupska, Ewa Jasiczek, Jakub Dobrowolski, Piotr Radziwon-Balicka, Aneta Skomro, Robert Szuba, Andrzej Mazur, Grzegorz Doroszko, Adrian Biomed Res Int Research Article The aim of the study was to assess the impact of regular professional sports activity on the endothelial and platelet function in young men. The studied group were 79 young men (18–40 y, 25 athletes and 54 without any regular physical activity). The nitric oxide (NO) metabolic pathway intermediates, oxidative stress markers, mediators of inflammation, and platelet aggregation were measured. Flow mediated dilation (FMD) was studied before and after intravenous 16,0 g L-arginine infusion, which was repeated after oral administration of acetylsalicylic acid (ASA-75 mg/day) for 4 days. Both groups had similar demographic characteristics. In the athletes, there was significantly higher hsCRP level, better serum lipid profile, and lower pulse pressure. Greater baseline FMD in athletes and in response to L-arginine disappeared following ASA treatment. There were no differences in the levels of the NO pathway metabolites. The control group was characterized by higher PAI-1 following ASA treatment and sICAM-1 both at baseline and after ASA, but no differences in MDA and 6-keto-PGF-1 alpha and platelet aggregation were noted. Regular professional physical activity modulates endothelial but not platelet function and may thus exert an effect on overall cardiovascular risk. Hindawi 2017 2017-05-29 /pmc/articles/PMC5467294/ /pubmed/28630872 http://dx.doi.org/10.1155/2017/8715909 Text en Copyright © 2017 Katarzyna Podgórska et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Podgórska, Katarzyna
Derkacz, Arkadiusz
Szahidewicz-Krupska, Ewa
Jasiczek, Jakub
Dobrowolski, Piotr
Radziwon-Balicka, Aneta
Skomro, Robert
Szuba, Andrzej
Mazur, Grzegorz
Doroszko, Adrian
Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity
title Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity
title_full Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity
title_fullStr Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity
title_full_unstemmed Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity
title_short Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity
title_sort effect of regular aerobic activity in young healthy athletes on profile of endothelial function and platelet activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467294/
https://www.ncbi.nlm.nih.gov/pubmed/28630872
http://dx.doi.org/10.1155/2017/8715909
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