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Biophysical Mechanisms Mediating Fibrin Fiber Lysis

The formation and dissolution of blood clots is both a biochemical and a biomechanical process. While much of the chemistry has been worked out for both processes, the influence of biophysical properties is less well understood. This review considers the impact of several structural and mechanical p...

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Detalles Bibliográficos
Autor principal: Hudson, Nathan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467299/
https://www.ncbi.nlm.nih.gov/pubmed/28630861
http://dx.doi.org/10.1155/2017/2748340
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author Hudson, Nathan E.
author_facet Hudson, Nathan E.
author_sort Hudson, Nathan E.
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description The formation and dissolution of blood clots is both a biochemical and a biomechanical process. While much of the chemistry has been worked out for both processes, the influence of biophysical properties is less well understood. This review considers the impact of several structural and mechanical parameters on lytic rates of fibrin fibers. The influences of fiber and network architecture, fiber strain, FXIIIa cross-linking, and particle transport phenomena will be assessed. The importance of the mechanical aspects of fibrinolysis is emphasized, and future research avenues are discussed.
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spelling pubmed-54672992017-06-19 Biophysical Mechanisms Mediating Fibrin Fiber Lysis Hudson, Nathan E. Biomed Res Int Review Article The formation and dissolution of blood clots is both a biochemical and a biomechanical process. While much of the chemistry has been worked out for both processes, the influence of biophysical properties is less well understood. This review considers the impact of several structural and mechanical parameters on lytic rates of fibrin fibers. The influences of fiber and network architecture, fiber strain, FXIIIa cross-linking, and particle transport phenomena will be assessed. The importance of the mechanical aspects of fibrinolysis is emphasized, and future research avenues are discussed. Hindawi 2017 2017-05-28 /pmc/articles/PMC5467299/ /pubmed/28630861 http://dx.doi.org/10.1155/2017/2748340 Text en Copyright © 2017 Nathan E. Hudson. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hudson, Nathan E.
Biophysical Mechanisms Mediating Fibrin Fiber Lysis
title Biophysical Mechanisms Mediating Fibrin Fiber Lysis
title_full Biophysical Mechanisms Mediating Fibrin Fiber Lysis
title_fullStr Biophysical Mechanisms Mediating Fibrin Fiber Lysis
title_full_unstemmed Biophysical Mechanisms Mediating Fibrin Fiber Lysis
title_short Biophysical Mechanisms Mediating Fibrin Fiber Lysis
title_sort biophysical mechanisms mediating fibrin fiber lysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467299/
https://www.ncbi.nlm.nih.gov/pubmed/28630861
http://dx.doi.org/10.1155/2017/2748340
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