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Long Noncoding RNAs as Biomarkers in Cancer
Long noncoding RNAs (lncRNAs) are a relatively well-characterized class of noncoding RNA (ncRNA) molecules, involved in the regulation of various cell processes, including transcription, intracellular trafficking, and chromosome remodeling. Their deregulation has been associated with the development...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467329/ https://www.ncbi.nlm.nih.gov/pubmed/28634418 http://dx.doi.org/10.1155/2017/7243968 |
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author | Bolha, Luka Ravnik-Glavač, Metka Glavač, Damjan |
author_facet | Bolha, Luka Ravnik-Glavač, Metka Glavač, Damjan |
author_sort | Bolha, Luka |
collection | PubMed |
description | Long noncoding RNAs (lncRNAs) are a relatively well-characterized class of noncoding RNA (ncRNA) molecules, involved in the regulation of various cell processes, including transcription, intracellular trafficking, and chromosome remodeling. Their deregulation has been associated with the development and progression of various cancer types, the fact which makes them suitable as biomarkers for cancer diagnosis and prognosis. In recent years, detection of cancer-associated lncRNAs in body fluids of cancer patients has proven itself as an especially valuable method to effectively diagnose cancer. Cancer diagnosis and prognosis employing circulating lncRNAs are preferential when compared to classical biopsies of tumor tissues, especially due to their noninvasiveness, and have great potential for routine usage in clinical practice. Thus, this review focuses on summarizing the perspectives of lncRNAs as biomarkers in cancer, based on evaluating their expression profiles determined in body fluids of cancer patients. |
format | Online Article Text |
id | pubmed-5467329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54673292017-06-20 Long Noncoding RNAs as Biomarkers in Cancer Bolha, Luka Ravnik-Glavač, Metka Glavač, Damjan Dis Markers Review Article Long noncoding RNAs (lncRNAs) are a relatively well-characterized class of noncoding RNA (ncRNA) molecules, involved in the regulation of various cell processes, including transcription, intracellular trafficking, and chromosome remodeling. Their deregulation has been associated with the development and progression of various cancer types, the fact which makes them suitable as biomarkers for cancer diagnosis and prognosis. In recent years, detection of cancer-associated lncRNAs in body fluids of cancer patients has proven itself as an especially valuable method to effectively diagnose cancer. Cancer diagnosis and prognosis employing circulating lncRNAs are preferential when compared to classical biopsies of tumor tissues, especially due to their noninvasiveness, and have great potential for routine usage in clinical practice. Thus, this review focuses on summarizing the perspectives of lncRNAs as biomarkers in cancer, based on evaluating their expression profiles determined in body fluids of cancer patients. Hindawi 2017 2017-05-29 /pmc/articles/PMC5467329/ /pubmed/28634418 http://dx.doi.org/10.1155/2017/7243968 Text en Copyright © 2017 Luka Bolha et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bolha, Luka Ravnik-Glavač, Metka Glavač, Damjan Long Noncoding RNAs as Biomarkers in Cancer |
title | Long Noncoding RNAs as Biomarkers in Cancer |
title_full | Long Noncoding RNAs as Biomarkers in Cancer |
title_fullStr | Long Noncoding RNAs as Biomarkers in Cancer |
title_full_unstemmed | Long Noncoding RNAs as Biomarkers in Cancer |
title_short | Long Noncoding RNAs as Biomarkers in Cancer |
title_sort | long noncoding rnas as biomarkers in cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467329/ https://www.ncbi.nlm.nih.gov/pubmed/28634418 http://dx.doi.org/10.1155/2017/7243968 |
work_keys_str_mv | AT bolhaluka longnoncodingrnasasbiomarkersincancer AT ravnikglavacmetka longnoncodingrnasasbiomarkersincancer AT glavacdamjan longnoncodingrnasasbiomarkersincancer |