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Moxibustion Alleviates Injury in a Rat Focal Segmental Glomerulosclerosis Model
OBJECTIVES: To evaluate the therapeutic effects of moxibustion at Shenshu (BL-23) and Geshu (BL-17) acupoints in a focal segmental glomerulosclerosis (FSGS) model in rats. METHODS: A FSGS rat model was established by single nephrectomy and repeated injection of doxorubicin. The FSGS rats were random...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467354/ https://www.ncbi.nlm.nih.gov/pubmed/28630634 http://dx.doi.org/10.1155/2017/7169547 |
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author | Li, Yi Sun, Yuxia Zhang, Chunling Wang, Ke Shen, Peicheng Huang, Di Ma, Wen Zhang, Jin Li, Lin He, Liqun |
author_facet | Li, Yi Sun, Yuxia Zhang, Chunling Wang, Ke Shen, Peicheng Huang, Di Ma, Wen Zhang, Jin Li, Lin He, Liqun |
author_sort | Li, Yi |
collection | PubMed |
description | OBJECTIVES: To evaluate the therapeutic effects of moxibustion at Shenshu (BL-23) and Geshu (BL-17) acupoints in a focal segmental glomerulosclerosis (FSGS) model in rats. METHODS: A FSGS rat model was established by single nephrectomy and repeated injection of doxorubicin. The FSGS rats were randomly divided into the model group, losartan (positive control) group, Shenshu moxibustion group, and Geshu moxibustion group. Molecular indicators of kidney function and renal pathological changes were monitored. RESULTS: Urinary protein, serum creatinine, urea nitrogen, and serum uric acid were significantly reduced after 12-week intervention with losartan, Shenshu, or Geshu moxibustion. Renal α-SMA, FN, and TGF-β were also decreased, while podocin and nephrin protein and mRNA were increased. The pathological damage in renal tissue was obviously alleviated by all three treatments, which suggests that moxibustion may have similar efficacy to losartan in the treatment of FSGS. CONCLUSION: Moxibustion alleviates podocyte injury and inhibits renal interstitial fibrosis in the FSGS rat model, thereby minimizing the progression of glomerular sclerosis and improving renal function. |
format | Online Article Text |
id | pubmed-5467354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54673542017-06-19 Moxibustion Alleviates Injury in a Rat Focal Segmental Glomerulosclerosis Model Li, Yi Sun, Yuxia Zhang, Chunling Wang, Ke Shen, Peicheng Huang, Di Ma, Wen Zhang, Jin Li, Lin He, Liqun Evid Based Complement Alternat Med Research Article OBJECTIVES: To evaluate the therapeutic effects of moxibustion at Shenshu (BL-23) and Geshu (BL-17) acupoints in a focal segmental glomerulosclerosis (FSGS) model in rats. METHODS: A FSGS rat model was established by single nephrectomy and repeated injection of doxorubicin. The FSGS rats were randomly divided into the model group, losartan (positive control) group, Shenshu moxibustion group, and Geshu moxibustion group. Molecular indicators of kidney function and renal pathological changes were monitored. RESULTS: Urinary protein, serum creatinine, urea nitrogen, and serum uric acid were significantly reduced after 12-week intervention with losartan, Shenshu, or Geshu moxibustion. Renal α-SMA, FN, and TGF-β were also decreased, while podocin and nephrin protein and mRNA were increased. The pathological damage in renal tissue was obviously alleviated by all three treatments, which suggests that moxibustion may have similar efficacy to losartan in the treatment of FSGS. CONCLUSION: Moxibustion alleviates podocyte injury and inhibits renal interstitial fibrosis in the FSGS rat model, thereby minimizing the progression of glomerular sclerosis and improving renal function. Hindawi 2017 2017-05-28 /pmc/articles/PMC5467354/ /pubmed/28630634 http://dx.doi.org/10.1155/2017/7169547 Text en Copyright © 2017 Yi Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Li, Yi Sun, Yuxia Zhang, Chunling Wang, Ke Shen, Peicheng Huang, Di Ma, Wen Zhang, Jin Li, Lin He, Liqun Moxibustion Alleviates Injury in a Rat Focal Segmental Glomerulosclerosis Model |
title | Moxibustion Alleviates Injury in a Rat Focal Segmental Glomerulosclerosis Model |
title_full | Moxibustion Alleviates Injury in a Rat Focal Segmental Glomerulosclerosis Model |
title_fullStr | Moxibustion Alleviates Injury in a Rat Focal Segmental Glomerulosclerosis Model |
title_full_unstemmed | Moxibustion Alleviates Injury in a Rat Focal Segmental Glomerulosclerosis Model |
title_short | Moxibustion Alleviates Injury in a Rat Focal Segmental Glomerulosclerosis Model |
title_sort | moxibustion alleviates injury in a rat focal segmental glomerulosclerosis model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467354/ https://www.ncbi.nlm.nih.gov/pubmed/28630634 http://dx.doi.org/10.1155/2017/7169547 |
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