Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling

Loss-of-function (LOF) mutations in the endothelial cell (EC) enriched gene endoglin (ENG) causes the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to tr...

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Detalles Bibliográficos
Autores principales: Jin, Yi, Muhl, Lars, Burmakin, Mikhail, Wang, Yixin, Duchez, Anne-Claire, Betsholtz, Christer, Arthur, Helen M., Jakobsson, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467724/
https://www.ncbi.nlm.nih.gov/pubmed/28530660
http://dx.doi.org/10.1038/ncb3534

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