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Prostaglandin E2 inhibits Tr1 cell differentiation through suppression of c-Maf

Prostaglandin E2 (PGE2), a major lipid mediator abundant at inflammatory sites, acts as a proinflammatory agent in models of inflammatory/autoimmune diseases by promoting CD4 Th1/Th17 differentiation. Regulatory T cells, including the IL-10 producing Tr1 cells counterbalance the proinflammatory acti...

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Detalles Bibliográficos
Autores principales:	Hooper, Kirsten Mary, Kong, Weimin, Ganea, Doina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467903/ https://www.ncbi.nlm.nih.gov/pubmed/28604806 http://dx.doi.org/10.1371/journal.pone.0179184

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