Increased mortality from complications of pulmonary hypertension in patients undergoing transcatheter aortic valve replacement

Aortic stenosis (AS) leads to pulmonary hypertension (PH) and right ventricle (RV) failure. Our goal was to describe mortality related to postoperative complications in PH patients undergoing transcatheter aortic valve replacement (TAVR). Ninety-three TAVR patients were analyzed (controls, sPAP <...

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Autores principales: Parikh, Raj, Varghese, Benson, Khatoon, Huma N., Kovach, Julie A., Kavinsky, Clifford J., Tandon, Rajive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467925/
https://www.ncbi.nlm.nih.gov/pubmed/28597767
http://dx.doi.org/10.1177/2045893217697709
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author Parikh, Raj
Varghese, Benson
Khatoon, Huma N.
Kovach, Julie A.
Kavinsky, Clifford J.
Tandon, Rajive
author_facet Parikh, Raj
Varghese, Benson
Khatoon, Huma N.
Kovach, Julie A.
Kavinsky, Clifford J.
Tandon, Rajive
author_sort Parikh, Raj
collection PubMed
description Aortic stenosis (AS) leads to pulmonary hypertension (PH) and right ventricle (RV) failure. Our goal was to describe mortality related to postoperative complications in PH patients undergoing transcatheter aortic valve replacement (TAVR). Ninety-three TAVR patients were analyzed (controls, sPAP < 50 mmHg; cases, sPAP ≥ 50 mmHg). Significant findings in cases included increased mortality (365 days), post-TAVR atrioventricular block (AVB) and acute kidney injury (AKI), and increased mean length of stay (LOS). This novel study highlights complications of PH as independent risk factors for death and significant morbidity post TAVR. Optimization of preoperative volume status and RV afterload reduction, while addressing AVB and AKI, may play a vital role in reducing mortality and LOS.
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spelling pubmed-54679252017-06-20 Increased mortality from complications of pulmonary hypertension in patients undergoing transcatheter aortic valve replacement Parikh, Raj Varghese, Benson Khatoon, Huma N. Kovach, Julie A. Kavinsky, Clifford J. Tandon, Rajive Pulm Circ Research Articles Aortic stenosis (AS) leads to pulmonary hypertension (PH) and right ventricle (RV) failure. Our goal was to describe mortality related to postoperative complications in PH patients undergoing transcatheter aortic valve replacement (TAVR). Ninety-three TAVR patients were analyzed (controls, sPAP < 50 mmHg; cases, sPAP ≥ 50 mmHg). Significant findings in cases included increased mortality (365 days), post-TAVR atrioventricular block (AVB) and acute kidney injury (AKI), and increased mean length of stay (LOS). This novel study highlights complications of PH as independent risk factors for death and significant morbidity post TAVR. Optimization of preoperative volume status and RV afterload reduction, while addressing AVB and AKI, may play a vital role in reducing mortality and LOS. SAGE Publications 2017-05-12 /pmc/articles/PMC5467925/ /pubmed/28597767 http://dx.doi.org/10.1177/2045893217697709 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Articles
Parikh, Raj
Varghese, Benson
Khatoon, Huma N.
Kovach, Julie A.
Kavinsky, Clifford J.
Tandon, Rajive
Increased mortality from complications of pulmonary hypertension in patients undergoing transcatheter aortic valve replacement
title Increased mortality from complications of pulmonary hypertension in patients undergoing transcatheter aortic valve replacement
title_full Increased mortality from complications of pulmonary hypertension in patients undergoing transcatheter aortic valve replacement
title_fullStr Increased mortality from complications of pulmonary hypertension in patients undergoing transcatheter aortic valve replacement
title_full_unstemmed Increased mortality from complications of pulmonary hypertension in patients undergoing transcatheter aortic valve replacement
title_short Increased mortality from complications of pulmonary hypertension in patients undergoing transcatheter aortic valve replacement
title_sort increased mortality from complications of pulmonary hypertension in patients undergoing transcatheter aortic valve replacement
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467925/
https://www.ncbi.nlm.nih.gov/pubmed/28597767
http://dx.doi.org/10.1177/2045893217697709
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