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Neomycin, polymyxin B, and dexamethasone allergic reactions following periocular surgery

BACKGROUND: The aim of this study was to evaluate the rate of periocular allergic skin reactions to topical neomycin, polymyxin B, and dexamethasone (NPD) ophthalmic ointment. METHODS: A consecutive patient prospective study was performed. A total of 522 patients who had a procedure involving incisi...

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Autores principales: Moore, Nicholas A., Czyz, Craig N., Carter, Tracy D., Foster, Jill A., Cahill, Kenneth V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468176/
https://www.ncbi.nlm.nih.gov/pubmed/28608297
http://dx.doi.org/10.1186/s12348-017-0133-4
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author Moore, Nicholas A.
Czyz, Craig N.
Carter, Tracy D.
Foster, Jill A.
Cahill, Kenneth V.
author_facet Moore, Nicholas A.
Czyz, Craig N.
Carter, Tracy D.
Foster, Jill A.
Cahill, Kenneth V.
author_sort Moore, Nicholas A.
collection PubMed
description BACKGROUND: The aim of this study was to evaluate the rate of periocular allergic skin reactions to topical neomycin, polymyxin B, and dexamethasone (NPD) ophthalmic ointment. METHODS: A consecutive patient prospective study was performed. A total of 522 patients who had a procedure involving incision of the periocular skin with subsequent postoperative application of NPD ophthalmic ointment were included. Patients were evaluated for signs of allergy at 1 week postoperatively or prior if the patient had complaints. A periocular allergic reaction was defined as any periocular skin pruritus, erythema, edematous papules, vesicles, or plaques at the site of ointment application beyond that of the typical postprocedure presentation. The patients continued to be monitored for 30 days postoperatively. RESULTS: Of the 522 patients who completed the study, eight (1.5%) had a definitive periocular allergic contact dermatitis to the NPD ophthalmic ointment. Allergic presentation ranged from postoperative day 3 to 14. CONCLUSIONS: The rate of periocular allergic reactions to NPD ophthalmic ointment is significantly lower than reported in the literature for other topical preparations of neomycin and polymyxin B. The low rate of allergy in this study suggests that NPD ophthalmic ointment can safely be applied to the periocular skin with a very minimal risk of inciting an allergic reaction.
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spelling pubmed-54681762017-06-26 Neomycin, polymyxin B, and dexamethasone allergic reactions following periocular surgery Moore, Nicholas A. Czyz, Craig N. Carter, Tracy D. Foster, Jill A. Cahill, Kenneth V. J Ophthalmic Inflamm Infect Original Research BACKGROUND: The aim of this study was to evaluate the rate of periocular allergic skin reactions to topical neomycin, polymyxin B, and dexamethasone (NPD) ophthalmic ointment. METHODS: A consecutive patient prospective study was performed. A total of 522 patients who had a procedure involving incision of the periocular skin with subsequent postoperative application of NPD ophthalmic ointment were included. Patients were evaluated for signs of allergy at 1 week postoperatively or prior if the patient had complaints. A periocular allergic reaction was defined as any periocular skin pruritus, erythema, edematous papules, vesicles, or plaques at the site of ointment application beyond that of the typical postprocedure presentation. The patients continued to be monitored for 30 days postoperatively. RESULTS: Of the 522 patients who completed the study, eight (1.5%) had a definitive periocular allergic contact dermatitis to the NPD ophthalmic ointment. Allergic presentation ranged from postoperative day 3 to 14. CONCLUSIONS: The rate of periocular allergic reactions to NPD ophthalmic ointment is significantly lower than reported in the literature for other topical preparations of neomycin and polymyxin B. The low rate of allergy in this study suggests that NPD ophthalmic ointment can safely be applied to the periocular skin with a very minimal risk of inciting an allergic reaction. Springer Berlin Heidelberg 2017-06-12 /pmc/articles/PMC5468176/ /pubmed/28608297 http://dx.doi.org/10.1186/s12348-017-0133-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Moore, Nicholas A.
Czyz, Craig N.
Carter, Tracy D.
Foster, Jill A.
Cahill, Kenneth V.
Neomycin, polymyxin B, and dexamethasone allergic reactions following periocular surgery
title Neomycin, polymyxin B, and dexamethasone allergic reactions following periocular surgery
title_full Neomycin, polymyxin B, and dexamethasone allergic reactions following periocular surgery
title_fullStr Neomycin, polymyxin B, and dexamethasone allergic reactions following periocular surgery
title_full_unstemmed Neomycin, polymyxin B, and dexamethasone allergic reactions following periocular surgery
title_short Neomycin, polymyxin B, and dexamethasone allergic reactions following periocular surgery
title_sort neomycin, polymyxin b, and dexamethasone allergic reactions following periocular surgery
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468176/
https://www.ncbi.nlm.nih.gov/pubmed/28608297
http://dx.doi.org/10.1186/s12348-017-0133-4
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