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Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative
We evaluated 2,656 patients with type 1 diabetes mellitus and preserved renal function from the database of the Italian Association of Clinical Diabetologists network to identify clinical predictors for the development of chronic kidney disease. We measured estimated glomerular filtration rate (eGFR...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468280/ https://www.ncbi.nlm.nih.gov/pubmed/28607417 http://dx.doi.org/10.1038/s41598-017-03551-w |
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author | Piscitelli, Pamela Viazzi, Francesca Fioretto, Paola Giorda, Carlo Ceriello, Antonio Genovese, Stefano Russo, Giuseppina Guida, Pietro Pontremoli, Roberto De Cosmo, Salvatore |
author_facet | Piscitelli, Pamela Viazzi, Francesca Fioretto, Paola Giorda, Carlo Ceriello, Antonio Genovese, Stefano Russo, Giuseppina Guida, Pietro Pontremoli, Roberto De Cosmo, Salvatore |
author_sort | Piscitelli, Pamela |
collection | PubMed |
description | We evaluated 2,656 patients with type 1 diabetes mellitus and preserved renal function from the database of the Italian Association of Clinical Diabetologists network to identify clinical predictors for the development of chronic kidney disease. We measured estimated glomerular filtration rate (eGFR), urinary albumin excretion, HbA1c, lipids, blood pressure. Over a 5-year period 4.3% (n = 115) developed reduced eGFR (<60 ml/min/1.73 m(2)), 18.0% (n = 477) albuminuria, and 21.0% (n = 559) either one of the renal endpoints (CKD). Odds ratios for eGFR below 90 mL/min/1.73 m2 (1.48, P < 0.001), HbA1c (1.13, P = 0.002), triglycerides (1.04, P = 0.021 by 20 mg/dL), low density lipoprotein cholesterol (LDL-c) (0.95, P = 0.002 by 10 mg/dL) were independently related to the onset of CKD. Known duration of diabetes (1.15, P = 0.014 by 10 years), HbA1c (1.16, P = 0.001), triglycerides (1.05, P = 0.005 by 20 mg/dL), LDL-c (0.95, P = 0.003 by 10 mg/dL), antihypertensive treatment (2.28, P = 0.018) were related to the onset of albuminuria while age and presence of baseline eGFR values between 90 and 60 mL/min/1.73 m2, independently affected the developing of reduced eGFR (OR 1.95, P < 0.001 by 10 years and 2.92, P < 0.001). Patients with type 1 diabetes mellitus and unfavorable CV risk profile are at high risk of developing CKD. The two main traits of CKD share several determinants, although with some specificities. |
format | Online Article Text |
id | pubmed-5468280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54682802017-06-14 Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative Piscitelli, Pamela Viazzi, Francesca Fioretto, Paola Giorda, Carlo Ceriello, Antonio Genovese, Stefano Russo, Giuseppina Guida, Pietro Pontremoli, Roberto De Cosmo, Salvatore Sci Rep Article We evaluated 2,656 patients with type 1 diabetes mellitus and preserved renal function from the database of the Italian Association of Clinical Diabetologists network to identify clinical predictors for the development of chronic kidney disease. We measured estimated glomerular filtration rate (eGFR), urinary albumin excretion, HbA1c, lipids, blood pressure. Over a 5-year period 4.3% (n = 115) developed reduced eGFR (<60 ml/min/1.73 m(2)), 18.0% (n = 477) albuminuria, and 21.0% (n = 559) either one of the renal endpoints (CKD). Odds ratios for eGFR below 90 mL/min/1.73 m2 (1.48, P < 0.001), HbA1c (1.13, P = 0.002), triglycerides (1.04, P = 0.021 by 20 mg/dL), low density lipoprotein cholesterol (LDL-c) (0.95, P = 0.002 by 10 mg/dL) were independently related to the onset of CKD. Known duration of diabetes (1.15, P = 0.014 by 10 years), HbA1c (1.16, P = 0.001), triglycerides (1.05, P = 0.005 by 20 mg/dL), LDL-c (0.95, P = 0.003 by 10 mg/dL), antihypertensive treatment (2.28, P = 0.018) were related to the onset of albuminuria while age and presence of baseline eGFR values between 90 and 60 mL/min/1.73 m2, independently affected the developing of reduced eGFR (OR 1.95, P < 0.001 by 10 years and 2.92, P < 0.001). Patients with type 1 diabetes mellitus and unfavorable CV risk profile are at high risk of developing CKD. The two main traits of CKD share several determinants, although with some specificities. Nature Publishing Group UK 2017-06-12 /pmc/articles/PMC5468280/ /pubmed/28607417 http://dx.doi.org/10.1038/s41598-017-03551-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Piscitelli, Pamela Viazzi, Francesca Fioretto, Paola Giorda, Carlo Ceriello, Antonio Genovese, Stefano Russo, Giuseppina Guida, Pietro Pontremoli, Roberto De Cosmo, Salvatore Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative |
title | Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative |
title_full | Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative |
title_fullStr | Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative |
title_full_unstemmed | Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative |
title_short | Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative |
title_sort | predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the amd annals initiative |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468280/ https://www.ncbi.nlm.nih.gov/pubmed/28607417 http://dx.doi.org/10.1038/s41598-017-03551-w |
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