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Gorge Motions of Acetylcholinesterase Revealed by Microsecond Molecular Dynamics Simulations
Acetylcholinesterase, with a deep, narrow active-site gorge, attracts enormous interest due to its particularly high catalytic efficiency and its inhibitors used for treatment of Alzheimer’s disease. To facilitate the massive pass-through of the substrate and inhibitors, “breathing” motions to modul...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468367/ https://www.ncbi.nlm.nih.gov/pubmed/28607438 http://dx.doi.org/10.1038/s41598-017-03088-y |