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Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation

Non-invasive brain stimulation (NIBS) has been under investigation as adjunct treatment of various neurological disorders with variable success. One challenge is the limited knowledge on what would be effective neuronal targets for an intervention, combined with limited knowledge on the neuronal mec...

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Autores principales: Assenza, Giovanni, Capone, Fioravante, di Biase, Lazzaro, Ferreri, Florinda, Florio, Lucia, Guerra, Andrea, Marano, Massimo, Paolucci, Matteo, Ranieri, Federico, Salomone, Gaetano, Tombini, Mario, Thut, Gregor, Di Lazzaro, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468377/
https://www.ncbi.nlm.nih.gov/pubmed/28659788
http://dx.doi.org/10.3389/fnagi.2017.00189
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author Assenza, Giovanni
Capone, Fioravante
di Biase, Lazzaro
Ferreri, Florinda
Florio, Lucia
Guerra, Andrea
Marano, Massimo
Paolucci, Matteo
Ranieri, Federico
Salomone, Gaetano
Tombini, Mario
Thut, Gregor
Di Lazzaro, Vincenzo
author_facet Assenza, Giovanni
Capone, Fioravante
di Biase, Lazzaro
Ferreri, Florinda
Florio, Lucia
Guerra, Andrea
Marano, Massimo
Paolucci, Matteo
Ranieri, Federico
Salomone, Gaetano
Tombini, Mario
Thut, Gregor
Di Lazzaro, Vincenzo
author_sort Assenza, Giovanni
collection PubMed
description Non-invasive brain stimulation (NIBS) has been under investigation as adjunct treatment of various neurological disorders with variable success. One challenge is the limited knowledge on what would be effective neuronal targets for an intervention, combined with limited knowledge on the neuronal mechanisms of NIBS. Motivated on the one hand by recent evidence that oscillatory activities in neural systems play a role in orchestrating brain functions and dysfunctions, in particular those of neurological disorders specific of elderly patients, and on the other hand that NIBS techniques may be used to interact with these brain oscillations in a controlled way, we here explore the potential of modulating brain oscillations as an effective strategy for clinical NIBS interventions. We first review the evidence for abnormal oscillatory profiles to be associated with a range of neurological disorders of elderly (e.g., Parkinson’s disease (PD), Alzheimer’s disease (AD), stroke, epilepsy), and for these signals of abnormal network activity to normalize with treatment, and/or to be predictive of disease progression or recovery. We then ask the question to what extent existing NIBS protocols have been tailored to interact with these oscillations and possibly associated dysfunctions. Our review shows that, despite evidence for both reliable neurophysiological markers of specific oscillatory dis-functionalities in neurological disorders and NIBS protocols potentially able to interact with them, there are few applications of NIBS aiming to explore clinical outcomes of this interaction. Our review article aims to point out oscillatory markers of neurological, which are also suitable targets for modification by NIBS, in order to facilitate in future studies the matching of technical application to clinical targets.
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spelling pubmed-54683772017-06-28 Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation Assenza, Giovanni Capone, Fioravante di Biase, Lazzaro Ferreri, Florinda Florio, Lucia Guerra, Andrea Marano, Massimo Paolucci, Matteo Ranieri, Federico Salomone, Gaetano Tombini, Mario Thut, Gregor Di Lazzaro, Vincenzo Front Aging Neurosci Neuroscience Non-invasive brain stimulation (NIBS) has been under investigation as adjunct treatment of various neurological disorders with variable success. One challenge is the limited knowledge on what would be effective neuronal targets for an intervention, combined with limited knowledge on the neuronal mechanisms of NIBS. Motivated on the one hand by recent evidence that oscillatory activities in neural systems play a role in orchestrating brain functions and dysfunctions, in particular those of neurological disorders specific of elderly patients, and on the other hand that NIBS techniques may be used to interact with these brain oscillations in a controlled way, we here explore the potential of modulating brain oscillations as an effective strategy for clinical NIBS interventions. We first review the evidence for abnormal oscillatory profiles to be associated with a range of neurological disorders of elderly (e.g., Parkinson’s disease (PD), Alzheimer’s disease (AD), stroke, epilepsy), and for these signals of abnormal network activity to normalize with treatment, and/or to be predictive of disease progression or recovery. We then ask the question to what extent existing NIBS protocols have been tailored to interact with these oscillations and possibly associated dysfunctions. Our review shows that, despite evidence for both reliable neurophysiological markers of specific oscillatory dis-functionalities in neurological disorders and NIBS protocols potentially able to interact with them, there are few applications of NIBS aiming to explore clinical outcomes of this interaction. Our review article aims to point out oscillatory markers of neurological, which are also suitable targets for modification by NIBS, in order to facilitate in future studies the matching of technical application to clinical targets. Frontiers Media S.A. 2017-06-13 /pmc/articles/PMC5468377/ /pubmed/28659788 http://dx.doi.org/10.3389/fnagi.2017.00189 Text en Copyright © 2017 Assenza, Capone, di Biase, Ferreri, Florio, Guerra, Marano, Paolucci, Ranieri, Salomone, Tombini, Thut and Di Lazzaro. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Assenza, Giovanni
Capone, Fioravante
di Biase, Lazzaro
Ferreri, Florinda
Florio, Lucia
Guerra, Andrea
Marano, Massimo
Paolucci, Matteo
Ranieri, Federico
Salomone, Gaetano
Tombini, Mario
Thut, Gregor
Di Lazzaro, Vincenzo
Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation
title Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation
title_full Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation
title_fullStr Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation
title_full_unstemmed Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation
title_short Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation
title_sort oscillatory activities in neurological disorders of elderly: biomarkers to target for neuromodulation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468377/
https://www.ncbi.nlm.nih.gov/pubmed/28659788
http://dx.doi.org/10.3389/fnagi.2017.00189
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