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Issues in Continuous 24-h Core Body Temperature Monitoring in Humans Using an Ingestible Capsule Telemetric Sensor

BACKGROUND: There is increasing interest in the use of pill-sized ingestible capsule telemetric sensors for assessing core body temperature (Tc) as a potential indicator of variability in metabolic efficiency and thrifty metabolic traits. The aim of this study was to investigate the feasibility and...

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Autores principales: Monnard, Cathriona R., Fares, Elie-Jacques, Calonne, Julie, Miles-Chan, Jennifer L., Montani, Jean-Pierre, Durrer, Dominique, Schutz, Yves, Dulloo, Abdul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468423/
https://www.ncbi.nlm.nih.gov/pubmed/28659868
http://dx.doi.org/10.3389/fendo.2017.00130
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author Monnard, Cathriona R.
Fares, Elie-Jacques
Calonne, Julie
Miles-Chan, Jennifer L.
Montani, Jean-Pierre
Durrer, Dominique
Schutz, Yves
Dulloo, Abdul G.
author_facet Monnard, Cathriona R.
Fares, Elie-Jacques
Calonne, Julie
Miles-Chan, Jennifer L.
Montani, Jean-Pierre
Durrer, Dominique
Schutz, Yves
Dulloo, Abdul G.
author_sort Monnard, Cathriona R.
collection PubMed
description BACKGROUND: There is increasing interest in the use of pill-sized ingestible capsule telemetric sensors for assessing core body temperature (Tc) as a potential indicator of variability in metabolic efficiency and thrifty metabolic traits. The aim of this study was to investigate the feasibility and accuracy of measuring Tc using the CorTemp(®) system. METHODS: Tc was measured over an average of 20 h in 27 human subjects, with measurements of energy expenditure made in the overnight fasted state at rest, during standardized low-intensity physical activity and after a 600 kcal mixed meal. Validation of accuracy of the capsule sensors was made ex vivo against mercury and electronic thermometers across the physiological range (35–40°C) in morning and afternoon of 2 or 3 consecutive days. Comparisons between capsule sensors and thermometers were made using Bland–Altman analysis. Systematic bias, error, and temperature drift over time were assessed. RESULTS: The circadian Tc profile classically reported in free-living humans was confirmed. Significant increases in Tc (+0.2°C) were found in response to low-power cycling at 40–50 W (~3–4 METs), but no changes in Tc were detectable during low-level isometric leg press exercise (<2 METs) or during the peak postprandial thermogenesis induced by the 600 kcal meal. Issues of particular interest include fast “turbo” gut transit with expulsion time of <15 h after capsule ingestion in one out of every five subjects and sudden erratic readings in teletransmission of Tc. Furthermore, ex vivo validation revealed a substantial mean bias (exceeding ±0.5°C) between the Tc capsule readings and mercury or electronic thermometers in half of the capsules. When examined over 2 or 3 days, the initial bias (small or large) drifted in excess of ±0.5°C in one out of every four capsules. CONCLUSION: Since Tc is regulated within a very narrow range in the healthy homeotherm’s body (within 1°C), physiological investigations of Tc require great accuracy and precision (better than 0.1°C). Although ingestible capsule methodology appears of great interest for non-invasively monitoring the transit gut temperature, new technology requires a reduction in the inherent error of measurement and elimination of temperature drift and warrants more interlaboratory investigation on the above factors.
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spelling pubmed-54684232017-06-28 Issues in Continuous 24-h Core Body Temperature Monitoring in Humans Using an Ingestible Capsule Telemetric Sensor Monnard, Cathriona R. Fares, Elie-Jacques Calonne, Julie Miles-Chan, Jennifer L. Montani, Jean-Pierre Durrer, Dominique Schutz, Yves Dulloo, Abdul G. Front Endocrinol (Lausanne) Endocrinology BACKGROUND: There is increasing interest in the use of pill-sized ingestible capsule telemetric sensors for assessing core body temperature (Tc) as a potential indicator of variability in metabolic efficiency and thrifty metabolic traits. The aim of this study was to investigate the feasibility and accuracy of measuring Tc using the CorTemp(®) system. METHODS: Tc was measured over an average of 20 h in 27 human subjects, with measurements of energy expenditure made in the overnight fasted state at rest, during standardized low-intensity physical activity and after a 600 kcal mixed meal. Validation of accuracy of the capsule sensors was made ex vivo against mercury and electronic thermometers across the physiological range (35–40°C) in morning and afternoon of 2 or 3 consecutive days. Comparisons between capsule sensors and thermometers were made using Bland–Altman analysis. Systematic bias, error, and temperature drift over time were assessed. RESULTS: The circadian Tc profile classically reported in free-living humans was confirmed. Significant increases in Tc (+0.2°C) were found in response to low-power cycling at 40–50 W (~3–4 METs), but no changes in Tc were detectable during low-level isometric leg press exercise (<2 METs) or during the peak postprandial thermogenesis induced by the 600 kcal meal. Issues of particular interest include fast “turbo” gut transit with expulsion time of <15 h after capsule ingestion in one out of every five subjects and sudden erratic readings in teletransmission of Tc. Furthermore, ex vivo validation revealed a substantial mean bias (exceeding ±0.5°C) between the Tc capsule readings and mercury or electronic thermometers in half of the capsules. When examined over 2 or 3 days, the initial bias (small or large) drifted in excess of ±0.5°C in one out of every four capsules. CONCLUSION: Since Tc is regulated within a very narrow range in the healthy homeotherm’s body (within 1°C), physiological investigations of Tc require great accuracy and precision (better than 0.1°C). Although ingestible capsule methodology appears of great interest for non-invasively monitoring the transit gut temperature, new technology requires a reduction in the inherent error of measurement and elimination of temperature drift and warrants more interlaboratory investigation on the above factors. Frontiers Media S.A. 2017-06-13 /pmc/articles/PMC5468423/ /pubmed/28659868 http://dx.doi.org/10.3389/fendo.2017.00130 Text en Copyright © 2017 Monnard, Fares, Calonne, Miles-Chan, Montani, Durrer, Schutz and Dulloo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Monnard, Cathriona R.
Fares, Elie-Jacques
Calonne, Julie
Miles-Chan, Jennifer L.
Montani, Jean-Pierre
Durrer, Dominique
Schutz, Yves
Dulloo, Abdul G.
Issues in Continuous 24-h Core Body Temperature Monitoring in Humans Using an Ingestible Capsule Telemetric Sensor
title Issues in Continuous 24-h Core Body Temperature Monitoring in Humans Using an Ingestible Capsule Telemetric Sensor
title_full Issues in Continuous 24-h Core Body Temperature Monitoring in Humans Using an Ingestible Capsule Telemetric Sensor
title_fullStr Issues in Continuous 24-h Core Body Temperature Monitoring in Humans Using an Ingestible Capsule Telemetric Sensor
title_full_unstemmed Issues in Continuous 24-h Core Body Temperature Monitoring in Humans Using an Ingestible Capsule Telemetric Sensor
title_short Issues in Continuous 24-h Core Body Temperature Monitoring in Humans Using an Ingestible Capsule Telemetric Sensor
title_sort issues in continuous 24-h core body temperature monitoring in humans using an ingestible capsule telemetric sensor
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468423/
https://www.ncbi.nlm.nih.gov/pubmed/28659868
http://dx.doi.org/10.3389/fendo.2017.00130
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