Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models

Parkinson's disease (PD) is a neurodegenerative disorder with symptoms that progressively worsen with age. Pathologically, PD is characterized by the aggregation of α-synuclein in cells of the substantia nigra in the brain and loss of dopaminergic neurons. This pathology is associated with impa...

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Autores principales: Maulik, Malabika, Mitra, Swarup, Bult-Ito, Abel, Taylor, Barbara E., Vayndorf, Elena M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468440/
https://www.ncbi.nlm.nih.gov/pubmed/28659967
http://dx.doi.org/10.3389/fgene.2017.00077
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author Maulik, Malabika
Mitra, Swarup
Bult-Ito, Abel
Taylor, Barbara E.
Vayndorf, Elena M.
author_facet Maulik, Malabika
Mitra, Swarup
Bult-Ito, Abel
Taylor, Barbara E.
Vayndorf, Elena M.
author_sort Maulik, Malabika
collection PubMed
description Parkinson's disease (PD) is a neurodegenerative disorder with symptoms that progressively worsen with age. Pathologically, PD is characterized by the aggregation of α-synuclein in cells of the substantia nigra in the brain and loss of dopaminergic neurons. This pathology is associated with impaired movement and reduced cognitive function. The etiology of PD can be attributed to a combination of environmental and genetic factors. A popular animal model, the nematode roundworm Caenorhabditis elegans, has been frequently used to study the role of genetic and environmental factors in the molecular pathology and behavioral phenotypes associated with PD. The current review summarizes cellular markers and behavioral phenotypes in transgenic and toxin-induced PD models of C. elegans.
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spelling pubmed-54684402017-06-28 Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models Maulik, Malabika Mitra, Swarup Bult-Ito, Abel Taylor, Barbara E. Vayndorf, Elena M. Front Genet Genetics Parkinson's disease (PD) is a neurodegenerative disorder with symptoms that progressively worsen with age. Pathologically, PD is characterized by the aggregation of α-synuclein in cells of the substantia nigra in the brain and loss of dopaminergic neurons. This pathology is associated with impaired movement and reduced cognitive function. The etiology of PD can be attributed to a combination of environmental and genetic factors. A popular animal model, the nematode roundworm Caenorhabditis elegans, has been frequently used to study the role of genetic and environmental factors in the molecular pathology and behavioral phenotypes associated with PD. The current review summarizes cellular markers and behavioral phenotypes in transgenic and toxin-induced PD models of C. elegans. Frontiers Media S.A. 2017-06-13 /pmc/articles/PMC5468440/ /pubmed/28659967 http://dx.doi.org/10.3389/fgene.2017.00077 Text en Copyright © 2017 Maulik, Mitra, Bult-Ito, Taylor and Vayndorf. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Maulik, Malabika
Mitra, Swarup
Bult-Ito, Abel
Taylor, Barbara E.
Vayndorf, Elena M.
Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models
title Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models
title_full Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models
title_fullStr Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models
title_full_unstemmed Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models
title_short Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models
title_sort behavioral phenotyping and pathological indicators of parkinson's disease in c. elegans models
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468440/
https://www.ncbi.nlm.nih.gov/pubmed/28659967
http://dx.doi.org/10.3389/fgene.2017.00077
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