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A polymorphism in the OPRM1 3′ untranslated region is associated with methadone efficacy in treating opioid dependence

The mu-opioid receptor (MOR) is the primary target of methadone and buprenorphine. The primary neuronal transcript of the OPRM1 gene, MOR-1, contains a ~13kb 3′ untranslated region with five common haplotypes in European-Americans. We analyzed the effects of these haplotypes on the percentage of opi...

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Detalles Bibliográficos
Autores principales:	Crist, Richard C., Doyle, Glenn A., Nelson, Elliot C., Degenhardt, Louisa, Martin, Nicholas G., Montgomery, Grant W., Saxon, Andrew J., Ling, Walter, Berrettini, Wade H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468510/ https://www.ncbi.nlm.nih.gov/pubmed/27958381 http://dx.doi.org/10.1038/tpj.2016.89

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