Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant

We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricula...

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Autores principales: Lin, Lisheng, Takahashi-Igari, Miho, Kato, Yoshiaki, Nozaki, Yoshihiro, Obata, Mana, Hamada, Hiromi, Horigome, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468569/
https://www.ncbi.nlm.nih.gov/pubmed/28638671
http://dx.doi.org/10.1155/2017/6570465
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author Lin, Lisheng
Takahashi-Igari, Miho
Kato, Yoshiaki
Nozaki, Yoshihiro
Obata, Mana
Hamada, Hiromi
Horigome, Hitoshi
author_facet Lin, Lisheng
Takahashi-Igari, Miho
Kato, Yoshiaki
Nozaki, Yoshihiro
Obata, Mana
Hamada, Hiromi
Horigome, Hitoshi
author_sort Lin, Lisheng
collection PubMed
description We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricular arrhythmias were confirmed after birth. Genetic testing of the baby revealed a SCN5A R1193Q variant, which we considered could account for the various arrhythmias in this case.
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spelling pubmed-54685692017-06-21 Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant Lin, Lisheng Takahashi-Igari, Miho Kato, Yoshiaki Nozaki, Yoshihiro Obata, Mana Hamada, Hiromi Horigome, Hitoshi Case Rep Pediatr Case Report We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricular arrhythmias were confirmed after birth. Genetic testing of the baby revealed a SCN5A R1193Q variant, which we considered could account for the various arrhythmias in this case. Hindawi 2017 2017-05-30 /pmc/articles/PMC5468569/ /pubmed/28638671 http://dx.doi.org/10.1155/2017/6570465 Text en Copyright © 2017 Lisheng Lin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lin, Lisheng
Takahashi-Igari, Miho
Kato, Yoshiaki
Nozaki, Yoshihiro
Obata, Mana
Hamada, Hiromi
Horigome, Hitoshi
Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
title Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
title_full Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
title_fullStr Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
title_full_unstemmed Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
title_short Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
title_sort prenatal diagnosis of atrioventricular block and qt interval prolongation by fetal magnetocardiography in a fetus with trisomy 18 and scn5a r1193q variant
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468569/
https://www.ncbi.nlm.nih.gov/pubmed/28638671
http://dx.doi.org/10.1155/2017/6570465
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