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Analysis of Clinical Characteristics of Immune-Related Dry Eye

AIM: To discuss the clinical characteristics of immune-related dry eye. METHODS: Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, includin...

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Autores principales: Wang, Hua, Wang, Ping-Bao, Chen, Ting, Zou, Jing, Li, Ya-Jia, Ran, Xu-Fang, Li, Qiang-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468589/
https://www.ncbi.nlm.nih.gov/pubmed/28638660
http://dx.doi.org/10.1155/2017/8532397
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author Wang, Hua
Wang, Ping-Bao
Chen, Ting
Zou, Jing
Li, Ya-Jia
Ran, Xu-Fang
Li, Qiang-Xiang
author_facet Wang, Hua
Wang, Ping-Bao
Chen, Ting
Zou, Jing
Li, Ya-Jia
Ran, Xu-Fang
Li, Qiang-Xiang
author_sort Wang, Hua
collection PubMed
description AIM: To discuss the clinical characteristics of immune-related dry eye. METHODS: Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, including 70 cases of Sjögren's syndrome (SS), 72 cases of systemic lupus erythematosus (SLE), and 65 cases of rheumatoid arthritis (RA). The classification of all patients was performed. The difference between the two groups was compared, including age, gender, ocular surface fluorescein staining and inflammatory reaction, tear breakup time (TBUT), Shirmer I test, confocal microscopy scan, and dry eye grading. RESULTS: Compared with the SDE group, the patients of IRDE group were younger (P < 0.05). The female patients were significantly more than the male ones (P < 0.05). Corneal staining counts and ocular surface inflammation were significantly increased (P < 0.05). TBUT and Shirmer I test shortened significantly (P < 0.05). Corneal nerve fibers were less, and the number of local lymphocyte was significant increased. The number of dry eye patients in the moderate or above IRDE group was significantly increased (P < 0.05). CONCLUSIONS: The dry eye symptom and sign and ocular surface inflammation of IRDE were significantly more severe than those of the SDE.
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spelling pubmed-54685892017-06-21 Analysis of Clinical Characteristics of Immune-Related Dry Eye Wang, Hua Wang, Ping-Bao Chen, Ting Zou, Jing Li, Ya-Jia Ran, Xu-Fang Li, Qiang-Xiang J Ophthalmol Research Article AIM: To discuss the clinical characteristics of immune-related dry eye. METHODS: Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, including 70 cases of Sjögren's syndrome (SS), 72 cases of systemic lupus erythematosus (SLE), and 65 cases of rheumatoid arthritis (RA). The classification of all patients was performed. The difference between the two groups was compared, including age, gender, ocular surface fluorescein staining and inflammatory reaction, tear breakup time (TBUT), Shirmer I test, confocal microscopy scan, and dry eye grading. RESULTS: Compared with the SDE group, the patients of IRDE group were younger (P < 0.05). The female patients were significantly more than the male ones (P < 0.05). Corneal staining counts and ocular surface inflammation were significantly increased (P < 0.05). TBUT and Shirmer I test shortened significantly (P < 0.05). Corneal nerve fibers were less, and the number of local lymphocyte was significant increased. The number of dry eye patients in the moderate or above IRDE group was significantly increased (P < 0.05). CONCLUSIONS: The dry eye symptom and sign and ocular surface inflammation of IRDE were significantly more severe than those of the SDE. Hindawi 2017 2017-05-30 /pmc/articles/PMC5468589/ /pubmed/28638660 http://dx.doi.org/10.1155/2017/8532397 Text en Copyright © 2017 Hua Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Hua
Wang, Ping-Bao
Chen, Ting
Zou, Jing
Li, Ya-Jia
Ran, Xu-Fang
Li, Qiang-Xiang
Analysis of Clinical Characteristics of Immune-Related Dry Eye
title Analysis of Clinical Characteristics of Immune-Related Dry Eye
title_full Analysis of Clinical Characteristics of Immune-Related Dry Eye
title_fullStr Analysis of Clinical Characteristics of Immune-Related Dry Eye
title_full_unstemmed Analysis of Clinical Characteristics of Immune-Related Dry Eye
title_short Analysis of Clinical Characteristics of Immune-Related Dry Eye
title_sort analysis of clinical characteristics of immune-related dry eye
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468589/
https://www.ncbi.nlm.nih.gov/pubmed/28638660
http://dx.doi.org/10.1155/2017/8532397
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