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An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established m...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468592/ https://www.ncbi.nlm.nih.gov/pubmed/28638414 http://dx.doi.org/10.1155/2017/2480375 |
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author | Hron, Alexander J. Asakura, Atsushi |
author_facet | Hron, Alexander J. Asakura, Atsushi |
author_sort | Hron, Alexander J. |
collection | PubMed |
description | Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined. |
format | Online Article Text |
id | pubmed-5468592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54685922017-06-21 An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma Hron, Alexander J. Asakura, Atsushi Stem Cells Int Review Article Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined. Hindawi 2017 2017-05-30 /pmc/articles/PMC5468592/ /pubmed/28638414 http://dx.doi.org/10.1155/2017/2480375 Text en Copyright © 2017 Alexander J. Hron and Atsushi Asakura. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Hron, Alexander J. Asakura, Atsushi An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma |
title | An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma |
title_full | An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma |
title_fullStr | An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma |
title_full_unstemmed | An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma |
title_short | An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma |
title_sort | examination of the role of transcriptional and posttranscriptional regulation in rhabdomyosarcoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468592/ https://www.ncbi.nlm.nih.gov/pubmed/28638414 http://dx.doi.org/10.1155/2017/2480375 |
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