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An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established m...

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Detalles Bibliográficos
Autores principales: Hron, Alexander J., Asakura, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468592/
https://www.ncbi.nlm.nih.gov/pubmed/28638414
http://dx.doi.org/10.1155/2017/2480375
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author Hron, Alexander J.
Asakura, Atsushi
author_facet Hron, Alexander J.
Asakura, Atsushi
author_sort Hron, Alexander J.
collection PubMed
description Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined.
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spelling pubmed-54685922017-06-21 An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma Hron, Alexander J. Asakura, Atsushi Stem Cells Int Review Article Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined. Hindawi 2017 2017-05-30 /pmc/articles/PMC5468592/ /pubmed/28638414 http://dx.doi.org/10.1155/2017/2480375 Text en Copyright © 2017 Alexander J. Hron and Atsushi Asakura. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hron, Alexander J.
Asakura, Atsushi
An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
title An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
title_full An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
title_fullStr An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
title_full_unstemmed An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
title_short An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
title_sort examination of the role of transcriptional and posttranscriptional regulation in rhabdomyosarcoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468592/
https://www.ncbi.nlm.nih.gov/pubmed/28638414
http://dx.doi.org/10.1155/2017/2480375
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