Recapitulating the Micromechanical Behavior of Tension and Shear in a Biomimetic Hydrogel for Controlling Tenocyte Response

A fiber composite system is presented which recapitulates the fiber‐composite‐like nature of tissues and generates similar modes of shear and tension. The shear/tension ratio can be customized during composite manufacture and incorporates viable cells. The system is a valuable tool for mechanotransd...

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Detalles Bibliográficos
Autores principales: Patel, Dharmesh, Sharma, Sadhana, Bryant, Stephanie J., Screen, Hazel R. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469035/
https://www.ncbi.nlm.nih.gov/pubmed/28026126
http://dx.doi.org/10.1002/adhm.201601095
Descripción
Sumario:A fiber composite system is presented which recapitulates the fiber‐composite‐like nature of tissues and generates similar modes of shear and tension. The shear/tension ratio can be customized during composite manufacture and incorporates viable cells. The system is a valuable tool for mechanotransduction research, providing a platform with physiologically relevant conditions for investigating cell behavior in different tissue types. [Image: see text]

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