Detection of gene-environment interactions in the presence of linkage disequilibrium and noise by using genetic risk scores with internal weights from elastic net regression

BACKGROUND: For the analysis of gene-environment (GxE) interactions commonly single nucleotide polymorphisms (SNPs) are used to characterize genetic susceptibility, an approach that mostly lacks power and has poor reproducibility. One promising approach to overcome this problem might be the use of w...

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Detalles Bibliográficos
Autores principales: Hüls, Anke, Ickstadt, Katja, Schikowski, Tamara, Krämer, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469185/
https://www.ncbi.nlm.nih.gov/pubmed/28606108
http://dx.doi.org/10.1186/s12863-017-0519-1

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