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The association of dyslipidemia and obesity with glycated hemoglobin

BACKGROUND: Dyslipidemia and obesity are the most common complex metabolic disorders taking the highest toll of health resources globally by its increasing incidences. This consequently leads to type 2 diabetes mellitus (T2DM) and cardiovascular disorders (CVDs) with variable reports about the role...

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Autores principales: Sheth, Jayesh, Shah, Ankna, Sheth, Frenny, Trivedi, Sunil, Nabar, Nutan, Shah, Navneet, Thakor, Premal, Vaidya, Rama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469195/
https://www.ncbi.nlm.nih.gov/pubmed/28702225
http://dx.doi.org/10.1186/s40842-015-0004-6
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author Sheth, Jayesh
Shah, Ankna
Sheth, Frenny
Trivedi, Sunil
Nabar, Nutan
Shah, Navneet
Thakor, Premal
Vaidya, Rama
author_facet Sheth, Jayesh
Shah, Ankna
Sheth, Frenny
Trivedi, Sunil
Nabar, Nutan
Shah, Navneet
Thakor, Premal
Vaidya, Rama
author_sort Sheth, Jayesh
collection PubMed
description BACKGROUND: Dyslipidemia and obesity are the most common complex metabolic disorders taking the highest toll of health resources globally by its increasing incidences. This consequently leads to type 2 diabetes mellitus (T2DM) and cardiovascular disorders (CVDs) with variable reports about the role of metabolic factors on glycemic control. The current study is designed to determine the association of dyslipidemia and obesity with glycated hemoglobin (HbA1c) in T2DM and non-diabetic subjects. METHODS: The present study was carried out in 931 subjects from urban Western India including 430 diabetic and 501 non-diabetic subjects with detailed anthropometric parameters. All subjects were investigated for HbA1c and lipid parameters like TC, TG, HDL-C, LDL-C and non-HDL-C. RESULTS: Dyslipidemia, central- and peripheral- obesity were observed (50.27 %; 75 % and 59.83 %) in all the study subjects respectively. Additionally, hyper-non-HDL-C was detected in 23.49 % and 22.56 % in T2DM and non-diabetic subjects. Significant linear associations of hyper-TC, hyper-LDL-C and hyper-non-HDL-C were observed with HbA1c in T2DM and non-diabetic control subjects respectively. Centrally- and peripherally- obese dyslipidemic subjects also showed a significant association with HbA1c in T2DM and control subjects respectively. CONCLUSION: This study demonstrates the high prevalence of dyslipidemia and obesity in all subjects irrespective of their disease status in a Western Indian population. The dyslipidemic obese subjects had significant linear association with HbA1c in T2DM subjects.
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spelling pubmed-54691952017-07-12 The association of dyslipidemia and obesity with glycated hemoglobin Sheth, Jayesh Shah, Ankna Sheth, Frenny Trivedi, Sunil Nabar, Nutan Shah, Navneet Thakor, Premal Vaidya, Rama Clin Diabetes Endocrinol Research Article BACKGROUND: Dyslipidemia and obesity are the most common complex metabolic disorders taking the highest toll of health resources globally by its increasing incidences. This consequently leads to type 2 diabetes mellitus (T2DM) and cardiovascular disorders (CVDs) with variable reports about the role of metabolic factors on glycemic control. The current study is designed to determine the association of dyslipidemia and obesity with glycated hemoglobin (HbA1c) in T2DM and non-diabetic subjects. METHODS: The present study was carried out in 931 subjects from urban Western India including 430 diabetic and 501 non-diabetic subjects with detailed anthropometric parameters. All subjects were investigated for HbA1c and lipid parameters like TC, TG, HDL-C, LDL-C and non-HDL-C. RESULTS: Dyslipidemia, central- and peripheral- obesity were observed (50.27 %; 75 % and 59.83 %) in all the study subjects respectively. Additionally, hyper-non-HDL-C was detected in 23.49 % and 22.56 % in T2DM and non-diabetic subjects. Significant linear associations of hyper-TC, hyper-LDL-C and hyper-non-HDL-C were observed with HbA1c in T2DM and non-diabetic control subjects respectively. Centrally- and peripherally- obese dyslipidemic subjects also showed a significant association with HbA1c in T2DM and control subjects respectively. CONCLUSION: This study demonstrates the high prevalence of dyslipidemia and obesity in all subjects irrespective of their disease status in a Western Indian population. The dyslipidemic obese subjects had significant linear association with HbA1c in T2DM subjects. BioMed Central 2015-06-23 /pmc/articles/PMC5469195/ /pubmed/28702225 http://dx.doi.org/10.1186/s40842-015-0004-6 Text en © Sheth et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Sheth, Jayesh
Shah, Ankna
Sheth, Frenny
Trivedi, Sunil
Nabar, Nutan
Shah, Navneet
Thakor, Premal
Vaidya, Rama
The association of dyslipidemia and obesity with glycated hemoglobin
title The association of dyslipidemia and obesity with glycated hemoglobin
title_full The association of dyslipidemia and obesity with glycated hemoglobin
title_fullStr The association of dyslipidemia and obesity with glycated hemoglobin
title_full_unstemmed The association of dyslipidemia and obesity with glycated hemoglobin
title_short The association of dyslipidemia and obesity with glycated hemoglobin
title_sort association of dyslipidemia and obesity with glycated hemoglobin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469195/
https://www.ncbi.nlm.nih.gov/pubmed/28702225
http://dx.doi.org/10.1186/s40842-015-0004-6
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