Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1

A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For HIV-1 infection, during entry, the virus triggers early actin activity by hijacking chemokine coreceptor signaling, which activates a host dependency factor, cofilin, and its kinase, the LIM d...

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Detalles Bibliográficos
Autores principales: Yi, Fei, Guo, Jia, Dabbagh, Deemah, Spear, Mark, He, Sijia, Kehn-Hall, Kylene, Fontenot, Jacque, Yin, Yan, Bibian, Mathieu, Park, Chul Min, Zheng, Ke, Park, Ha Jeung, Soloveva, Veronica, Gharaibeh, Dima, Retterer, Cary, Zamani, Rouzbeh, Pitt, Margaret L., Naughton, John, Jiang, Yongjun, Shang, Hong, Hakami, Ramin M., Ling, Binhua, Young, John A. T., Bavari, Sina, Xu, Xuehua, Feng, Yangbo, Wu, Yuntao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469273/
https://www.ncbi.nlm.nih.gov/pubmed/28381571
http://dx.doi.org/10.1128/JVI.02418-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469273/
https://www.ncbi.nlm.nih.gov/pubmed/28381571
http://dx.doi.org/10.1128/JVI.02418-16

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