Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice

We analyzed hematopoietic phenotypes in Peromyscus leucopus (PL) mice at young (2–9 months), middle (22–23 months) and old (33–46 months) ages aimed at characterizing age-associated changes in this unique rodent species. We found a significantly higher number of monocytes in old PL mice in periphera...

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Detalles Bibliográficos
Autores principales: Lin, Zenghua, Kajigaya, Sachiko, Feng, Xingmin, Chen, Jichun, Young, Neal S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469418/
https://www.ncbi.nlm.nih.gov/pubmed/28620625
http://dx.doi.org/10.4172/2329-8847.1000169
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author Lin, Zenghua
Kajigaya, Sachiko
Feng, Xingmin
Chen, Jichun
Young, Neal S
author_facet Lin, Zenghua
Kajigaya, Sachiko
Feng, Xingmin
Chen, Jichun
Young, Neal S
author_sort Lin, Zenghua
collection PubMed
description We analyzed hematopoietic phenotypes in Peromyscus leucopus (PL) mice at young (2–9 months), middle (22–23 months) and old (33–46 months) ages aimed at characterizing age-associated changes in this unique rodent species. We found a significantly higher number of monocytes in old PL mice in peripheral blood, and higher proportions of CD44(+) cells in blood, spleen and bone marrow in old PL mice than in middle and young counterparts. We conclude that elevated blood monocyte counts and up-regulated hematopoietic cell CD44 expression are two useful aging biomarkers for PL mice.
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spelling pubmed-54694182017-06-13 Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice Lin, Zenghua Kajigaya, Sachiko Feng, Xingmin Chen, Jichun Young, Neal S J Aging Sci Article We analyzed hematopoietic phenotypes in Peromyscus leucopus (PL) mice at young (2–9 months), middle (22–23 months) and old (33–46 months) ages aimed at characterizing age-associated changes in this unique rodent species. We found a significantly higher number of monocytes in old PL mice in peripheral blood, and higher proportions of CD44(+) cells in blood, spleen and bone marrow in old PL mice than in middle and young counterparts. We conclude that elevated blood monocyte counts and up-regulated hematopoietic cell CD44 expression are two useful aging biomarkers for PL mice. 2017-02-06 2017-04 /pmc/articles/PMC5469418/ /pubmed/28620625 http://dx.doi.org/10.4172/2329-8847.1000169 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Lin, Zenghua
Kajigaya, Sachiko
Feng, Xingmin
Chen, Jichun
Young, Neal S
Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice
title Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice
title_full Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice
title_fullStr Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice
title_full_unstemmed Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice
title_short Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice
title_sort hematopoietic aging biomarkers in peromyscus leucopus mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469418/
https://www.ncbi.nlm.nih.gov/pubmed/28620625
http://dx.doi.org/10.4172/2329-8847.1000169
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AT chenjichun hematopoieticagingbiomarkersinperomyscusleucopusmice
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