Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor

Family B G protein-coupled receptors (GPCRs) play vital roles in hormone-regulated homeostasis. They are drug targets for metabolic diseases, including type 2 diabetes and osteoporosis. Despite their importance, the signaling mechanisms for family B GPCRs at the molecular level remain largely unexpl...

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Detalles Bibliográficos
Autores principales: Cai, Yingying, Liu, Yuting, Culhane, Kelly J., DeVree, Brian T., Yang, Yang, Sunahara, Roger K., Yan, Elsa C. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469476/
https://www.ncbi.nlm.nih.gov/pubmed/28609478
http://dx.doi.org/10.1371/journal.pone.0179568

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