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Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis
Amyloidosis is associated with a number of rare diseases and is characterized by the deposition, in abdominothoracic organs and peripheral nerves, of extracellular protein fibrils, which leads to dysfunction and severe morbidity. Effective clinical evaluation and management of patients with systemic...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469514/ https://www.ncbi.nlm.nih.gov/pubmed/28654386 http://dx.doi.org/10.1177/1536012117708705 |
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author | Wall, Jonathan S. Kennel, Stephen J. Martin, Emily B. |
author_facet | Wall, Jonathan S. Kennel, Stephen J. Martin, Emily B. |
author_sort | Wall, Jonathan S. |
collection | PubMed |
description | Amyloidosis is associated with a number of rare diseases and is characterized by the deposition, in abdominothoracic organs and peripheral nerves, of extracellular protein fibrils, which leads to dysfunction and severe morbidity. Effective clinical evaluation and management of patients with systemic amyloidosis are hampered by the lack of a noninvasive, quantitative method for detecting whole-body amyloid load. We have used a battery of assays including dual-energy SPECT imaging and comparative effectiveness studies in support of translation of a synthetic polybasic peptide, p5+14, as a novel radiotracer for visualization of amyloidosis by molecular imaging. These data provide support for a phase 1 positron emission tomography/computed tomography imaging trial of this reagent, labeled with iodine-124, in patients with all forms of systemic amyloidosis. |
format | Online Article Text |
id | pubmed-5469514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-54695142017-06-22 Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis Wall, Jonathan S. Kennel, Stephen J. Martin, Emily B. Mol Imaging Commentaries Amyloidosis is associated with a number of rare diseases and is characterized by the deposition, in abdominothoracic organs and peripheral nerves, of extracellular protein fibrils, which leads to dysfunction and severe morbidity. Effective clinical evaluation and management of patients with systemic amyloidosis are hampered by the lack of a noninvasive, quantitative method for detecting whole-body amyloid load. We have used a battery of assays including dual-energy SPECT imaging and comparative effectiveness studies in support of translation of a synthetic polybasic peptide, p5+14, as a novel radiotracer for visualization of amyloidosis by molecular imaging. These data provide support for a phase 1 positron emission tomography/computed tomography imaging trial of this reagent, labeled with iodine-124, in patients with all forms of systemic amyloidosis. SAGE Publications 2017-05-11 /pmc/articles/PMC5469514/ /pubmed/28654386 http://dx.doi.org/10.1177/1536012117708705 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Commentaries Wall, Jonathan S. Kennel, Stephen J. Martin, Emily B. Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis |
title | Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis |
title_full | Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis |
title_fullStr | Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis |
title_full_unstemmed | Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis |
title_short | Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis |
title_sort | dual-energy spect and the development of peptide p5+14 for imaging amyloidosis |
topic | Commentaries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469514/ https://www.ncbi.nlm.nih.gov/pubmed/28654386 http://dx.doi.org/10.1177/1536012117708705 |
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