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Deletion of inositol-requiring enzyme-1α in podocytes disrupts glomerular capillary integrity and autophagy
Inositol-requiring enzyme-1α (IRE1α) is an endoplasmic reticulum (ER)–transmembrane endoribonuclease kinase that plays an essential function in extraembryonic tissues during normal development and is activated during ER stress. To address the functional role of IRE1α in glomerular podocytes, we prod...
Autores principales: | Kaufman, Daniel Robert, Papillon, Joan, Larose, Louise, Iwawaki, Takao, Cybulsky, Andrey V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469607/ https://www.ncbi.nlm.nih.gov/pubmed/28428258 http://dx.doi.org/10.1091/mbc.E16-12-0828 |
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