Enhanced chondrogenesis of bone marrow-derived stem cells by using a combinatory cell therapy strategy with BMP-2/TGF-β1, hypoxia, and COL1A1/HtrA1 siRNAs

Mesenchymal stem cells (MSCs) hold promise for cartilage engineering. Here, we aimed to determine the best culture conditions to induce chondrogenesis of MSCs isolated from bone marrow (BM) of aged osteoarthritis (OA) patients. We showed that these BM-MSCs proliferate slowly, are not uniformly posit...

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Detalles Bibliográficos
Autores principales: Legendre, Florence, Ollitrault, David, Gomez-Leduc, Tangni, Bouyoucef, Mouloud, Hervieu, Magalie, Gruchy, Nicolas, Mallein-Gerin, Frédéric, Leclercq, Sylvain, Demoor, Magali, Galéra, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469741/
https://www.ncbi.nlm.nih.gov/pubmed/28611369
http://dx.doi.org/10.1038/s41598-017-03579-y

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