Cargando…

Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail

Blood flow influences atherosclerosis by generating wall shear stress, which alters endothelial cell (EC) physiology. Low shear stress induces dedifferentiation of EC through a process termed endothelial-to-mesenchymal transition (EndMT). The mechanisms underlying shear stress-regulation of EndMT ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mahmoud, Marwa M., Serbanovic-Canic, Jovana, Feng, Shuang, Souilhol, Celine, Xing, Rouyu, Hsiao, Sarah, Mammoto, Akiko, Chen, Jing, Ariaans, Markus, Francis, Sheila E., Van der Heiden, Kim, Ridger, Victoria, Evans, Paul C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469771/ https://www.ncbi.nlm.nih.gov/pubmed/28611395 http://dx.doi.org/10.1038/s41598-017-03532-z

Ejemplares similares

Author Correction: Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail
por: Mahmoud, Marwa M., et al.
Publicado: (2020)

TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis
por: Mahmoud, Marwa M., et al.
Publicado: (2016)

Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites
por: Souilhol, Celine, et al.
Publicado: (2020)

EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy
por: Canham, Lindsay, et al.
Publicado: (2023)

Quantifying endothelial cell proliferation in the zebrafish embryo
por: Bowley, George, et al.
Publicado: (2021)

JAG1-NOTCH4 mechanosensing drives atherosclerosis
por: Souilhol, Celine, et al.
Publicado: (2022)

Zebrafish Model for Functional Screening of Flow-Responsive Genes
por: Serbanovic-Canic, Jovana, et al.
Publicado: (2017)

β1 integrin is a sensor of blood flow direction
por: Xanthis, Ioannis, et al.
Publicado: (2019)

Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites
por: Feng, Shuang, et al.
Publicado: (2017)

Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium
por: Gomez, Ingrid, et al.
Publicado: (2020)

The effect of absent blood flow on the zebrafish cerebral and trunk vasculature
por: Kugler, Elisabeth, et al.
Publicado: (2021)

Image-based characterization of thrombus formation in time-lapse DIC microscopy
por: Brieu, Nicolas, et al.
Publicado: (2012)

A Loss of Function Screen of Identified Genome-Wide Association Study Loci Reveals New Genes Controlling Hematopoiesis
por: Bielczyk-Maczyńska, Ewa, et al.
Publicado: (2014)

Endothelial Twist1-PDGFB signaling mediates hypoxia-induced proliferation and migration of αSMA-positive cells
por: Mammoto, Akiko, et al.
Publicado: (2020)

Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
por: Kyi, Priscilla, et al.
Publicado: (2022)

Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1
por: Mammoto, Tadanori, et al.
Publicado: (2019)

Vascular Niche in Lung Alveolar Development, Homeostasis, and Regeneration
por: Mammoto, Akiko, et al.
Publicado: (2019)

Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling
por: Green, Jack P, et al.
Publicado: (2018)

Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration
por: Mammoto, Tadanori, et al.
Publicado: (2022)

LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung
por: Mammoto, Akiko, et al.
Publicado: (2019)

Extracellular Matrix in Aging Aorta
por: Mammoto, Akiko, et al.
Publicado: (2022)

Heparan sulfate proteoglycan glypican-1 and PECAM-1 cooperate in shear-induced endothelial nitric oxide production
por: Bartosch, Anne Marie W., et al.
Publicado: (2021)

Editorial: Organ microenvironment in vascular formation, homeostasis and engineering
por: Mammoto, Akiko, et al.
Publicado: (2023)

Autophagy attenuates endothelial-to-mesenchymal transition by promoting Snail degradation in human cardiac microvascular endothelial cells
por: Zou, Jin, et al.
Publicado: (2017)

Angiopoietin-1 enhances neutrophil chemotaxis in vitro and migration in vivo through interaction with CD18 and release of CCL4
por: Burnett, Amanda, et al.
Publicado: (2017)

Non-Newtonian Endothelial Shear Stress Simulation: Does It Matter?
por: Thondapu, Vikas, et al.
Publicado: (2022)

The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial–Mesenchymal Transition
por: Sobierajska, Katarzyna, et al.
Publicado: (2020)

Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction
por: Fan, Min, et al.
Publicado: (2023)

Sitting and endothelial dysfunction: The role of shear stress
por: Thosar, Saurabh S., et al.
Publicado: (2012)

Fluid Shear Stress Sensing by the Endothelial Layer
por: Roux, Etienne, et al.
Publicado: (2020)

Twist1 signaling in age-dependent decline in angiogenesis and lung regeneration
por: Hendee, Kathryn, et al.
Publicado: (2021)

Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling
por: Hunyenyiwa, Tendai, et al.
Publicado: (2021)

TGF-β-Induced Endothelial to Mesenchymal Transition Is Determined by a Balance Between SNAIL and ID Factors
por: Ma, Jin, et al.
Publicado: (2021)

Cx43 Facilitates Mesenchymal Transition of Endothelial Cells Induced by Shear Stress
por: Zhou, En, et al.
Publicado: (2023)

Regulation of shear-induced nuclear translocation of the Nrf2 transcription factor in endothelial cells
por: Hsieh, Chung-Yu, et al.
Publicado: (2009)

Three Strigeid cercariae from Littorina littorea snail, Qarun Lake, Fayoum, Egypt
por: Bakry, Fayez A., et al.
Publicado: (2018)

Endothelial Mechanosensors for Atheroprone and Atheroprotective Shear Stress Signals
por: Li, Hui, et al.
Publicado: (2022)

Rictor maintains endothelial integrity under shear stress
por: Li, Hui, et al.
Publicado: (2022)

Paxillin Mediates Sensing of Physical Cues and Regulates Directional Cell Motility by Controlling Lamellipodia Positioning
por: Sero, Julia E., et al.
Publicado: (2011)

Endothelial Snail Regulates Capillary Branching Morphogenesis via Vascular Endothelial Growth Factor Receptor 3 Expression
por: Park, Jeong Ae, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_oln6q3uvqav912iudirtkppke6