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Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia
Acupuncture is an alternative treatment for wide spectrum chronic pain. However, its validity remains controversial due to the disputed efficacy assessed in various clinical studies. Moreover, variability amongst individuals complicates the predictability of outcome, which impedes the integration of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469855/ https://www.ncbi.nlm.nih.gov/pubmed/28611421 http://dx.doi.org/10.1038/s41598-017-03542-x |
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author | Fujita, Takumi Feng, Changyong Takano, Takahiro |
author_facet | Fujita, Takumi Feng, Changyong Takano, Takahiro |
author_sort | Fujita, Takumi |
collection | PubMed |
description | Acupuncture is an alternative treatment for wide spectrum chronic pain. However, its validity remains controversial due to the disputed efficacy assessed in various clinical studies. Moreover, variability amongst individuals complicates the predictability of outcome, which impedes the integration of acupuncture into mainstream pain management programs. In light of our previous finding that the analgesic effect of acupuncture is mediated by adenosine A1 receptor activation at the acupuncture point, we here report that in acute and chronic animal pain models, oral intake of caffeine, a potent adenosine receptor antagonist, interferes with acupuncture analgesia, even at a low dose. Local administration of caffeine at the acupuncture point was sufficient to eliminate the analgesic effect, dismissing the systemic action of caffeine. Such interference was reversible, as caffeine withdrawal fully restored the efficacy of acupuncture by the next day, and long-term exposure to caffeine did not alter A1 receptor expression at the acupuncture point. Combined, these data indicate that a trace amount of caffeine can reversibly block the analgesic effects of acupuncture, and controlling caffeine consumption during acupuncture may improve pain management outcomes. |
format | Online Article Text |
id | pubmed-5469855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54698552017-06-19 Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia Fujita, Takumi Feng, Changyong Takano, Takahiro Sci Rep Article Acupuncture is an alternative treatment for wide spectrum chronic pain. However, its validity remains controversial due to the disputed efficacy assessed in various clinical studies. Moreover, variability amongst individuals complicates the predictability of outcome, which impedes the integration of acupuncture into mainstream pain management programs. In light of our previous finding that the analgesic effect of acupuncture is mediated by adenosine A1 receptor activation at the acupuncture point, we here report that in acute and chronic animal pain models, oral intake of caffeine, a potent adenosine receptor antagonist, interferes with acupuncture analgesia, even at a low dose. Local administration of caffeine at the acupuncture point was sufficient to eliminate the analgesic effect, dismissing the systemic action of caffeine. Such interference was reversible, as caffeine withdrawal fully restored the efficacy of acupuncture by the next day, and long-term exposure to caffeine did not alter A1 receptor expression at the acupuncture point. Combined, these data indicate that a trace amount of caffeine can reversibly block the analgesic effects of acupuncture, and controlling caffeine consumption during acupuncture may improve pain management outcomes. Nature Publishing Group UK 2017-06-13 /pmc/articles/PMC5469855/ /pubmed/28611421 http://dx.doi.org/10.1038/s41598-017-03542-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Fujita, Takumi Feng, Changyong Takano, Takahiro Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia |
title | Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia |
title_full | Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia |
title_fullStr | Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia |
title_full_unstemmed | Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia |
title_short | Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia |
title_sort | presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469855/ https://www.ncbi.nlm.nih.gov/pubmed/28611421 http://dx.doi.org/10.1038/s41598-017-03542-x |
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