Cargando…
Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin
The potent calcium channel blocker ω-conotoxin MVIIA is a linear cystine-knot peptide with multiple basic amino acids at both termini. This work shows that macrocyclization of MVIIA linking two positive-charge terminal clusters as a contiguous segment converts a conotoxin into an antimicrobial pepti...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Bentham Science Publishers
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470054/ https://www.ncbi.nlm.nih.gov/pubmed/28245769 http://dx.doi.org/10.2174/1381612822666161027120518 |