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Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma
PURPOSE: The aim of this study was to report a case of atopic dermatitis showing elevated intraocular pressure (IOP) beyond the baseline levels followed by a modified 360-degree suture trabeculotomy, and to analyze the histological findings in the trabecular meshwork. METHODS: A 40-year-old male suf...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Open
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470058/ https://www.ncbi.nlm.nih.gov/pubmed/28660005 http://dx.doi.org/10.2174/1874364101711010103 |
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author | Kase, Satoru Chin, Shiki Hamanaka, Teruhiko Shinmei, Yasuhiro Ohguchi, Takeshi Kijima, Riki Matsuda, Akira Ishida, Susumu |
author_facet | Kase, Satoru Chin, Shiki Hamanaka, Teruhiko Shinmei, Yasuhiro Ohguchi, Takeshi Kijima, Riki Matsuda, Akira Ishida, Susumu |
author_sort | Kase, Satoru |
collection | PubMed |
description | PURPOSE: The aim of this study was to report a case of atopic dermatitis showing elevated intraocular pressure (IOP) beyond the baseline levels followed by a modified 360-degree suture trabeculotomy, and to analyze the histological findings in the trabecular meshwork. METHODS: A 40-year-old male suffered from blurred vision in the right eye (OD). He had a medical history of severe atopic dermatitis and intraocular lens implantation OU due to atopic cataract. At the initial presentation, the visual acuity was 0.03, and IOP was 35 mmHg OD. Slit-lamp examination demonstrated corneal epithelial edema OD. Increased IOP was refractory to several topical medications. The patient underwent a modified 360-degree suture trabeculotomy. The visual field defect, however, deteriorated with persistently high IOP. The patient underwent trabeculectomy together with drainage implant surgery. In the outflow routes, although there seemed to be an opening of Schlemm’s canal into the anterior chamber, there was no endothelium of the canal in the region of its opening. The fibrotic changes were conspicuous around Schlemm’s canal. CONCLUSION: The histological results indicated that trabeculotomy might not be an appropriate treatment for patients with atopic glaucoma, possibly because of excessive repair to the newly created uveoscleral outflow in addition to the increased postoperative fibrosis in the trabecular meshwork and Schlemm’s canal. |
format | Online Article Text |
id | pubmed-5470058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-54700582017-06-28 Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma Kase, Satoru Chin, Shiki Hamanaka, Teruhiko Shinmei, Yasuhiro Ohguchi, Takeshi Kijima, Riki Matsuda, Akira Ishida, Susumu Open Ophthalmol J Article PURPOSE: The aim of this study was to report a case of atopic dermatitis showing elevated intraocular pressure (IOP) beyond the baseline levels followed by a modified 360-degree suture trabeculotomy, and to analyze the histological findings in the trabecular meshwork. METHODS: A 40-year-old male suffered from blurred vision in the right eye (OD). He had a medical history of severe atopic dermatitis and intraocular lens implantation OU due to atopic cataract. At the initial presentation, the visual acuity was 0.03, and IOP was 35 mmHg OD. Slit-lamp examination demonstrated corneal epithelial edema OD. Increased IOP was refractory to several topical medications. The patient underwent a modified 360-degree suture trabeculotomy. The visual field defect, however, deteriorated with persistently high IOP. The patient underwent trabeculectomy together with drainage implant surgery. In the outflow routes, although there seemed to be an opening of Schlemm’s canal into the anterior chamber, there was no endothelium of the canal in the region of its opening. The fibrotic changes were conspicuous around Schlemm’s canal. CONCLUSION: The histological results indicated that trabeculotomy might not be an appropriate treatment for patients with atopic glaucoma, possibly because of excessive repair to the newly created uveoscleral outflow in addition to the increased postoperative fibrosis in the trabecular meshwork and Schlemm’s canal. Bentham Open 2017-05-29 /pmc/articles/PMC5470058/ /pubmed/28660005 http://dx.doi.org/10.2174/1874364101711010103 Text en © 2017 Kase et al. https://creativecommons.org/licenses/by/4.0/legalcode This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Article Kase, Satoru Chin, Shiki Hamanaka, Teruhiko Shinmei, Yasuhiro Ohguchi, Takeshi Kijima, Riki Matsuda, Akira Ishida, Susumu Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma |
title | Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma |
title_full | Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma |
title_fullStr | Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma |
title_full_unstemmed | Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma |
title_short | Histological Findings in the Trabecular Meshwork of a Patient with Atopic Glaucoma |
title_sort | histological findings in the trabecular meshwork of a patient with atopic glaucoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470058/ https://www.ncbi.nlm.nih.gov/pubmed/28660005 http://dx.doi.org/10.2174/1874364101711010103 |
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