Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI

The aim of this study is to evaluate the localization of (99m)Tc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered (99m)Tc-SPIO intravenously or intra-arterially (IA) with/without Lipiodol to compare the tumor localiz...

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Detalles Bibliográficos
Autores principales: Lee, In Joon, Park, Ji Yong, Kim, Young-il, Lee, Yun-Sang, Jeong, Jae Min, Kim, Jaeil, Kim, Euishin Edmund, Kang, Keon Wook, Lee, Dong Soo, Jeong, Seonji, Kim, Eun Jeong, Kim, Young Il, Chung, Jin Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470132/
https://www.ncbi.nlm.nih.gov/pubmed/28654377
http://dx.doi.org/10.1177/1536012116689001
Descripción
Sumario:The aim of this study is to evaluate the localization of (99m)Tc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered (99m)Tc-SPIO intravenously or intra-arterially (IA) with/without Lipiodol to compare the tumor localization by gamma scintigraphy, single-photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) in a rabbit liver tumor. The gamma and SPECT image-based analysis shows that the uptake ratio of the tumor to the normal liver parenchyma is highest after delivery of (99m)Tc-SPIO with Lipiodol IA and that well correlates with the trend of the signal decrease in the liver MRIs. Intra-arterial delivery of SPIO with Lipiodol might be a good drug delivery system targeting the hepatic tumors, as confirmed by image-based analysis.

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