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Dorsal Sural Sensory Nerve Action Potential: A Study for Reference Values

BACKGROUND: Dorsal sural sensory nerve action potential (SNAP) could help diagnose early or subclinical peripheral neuropathy. OBJECTIVES: To establish reference data for dorsal sural SNAP amplitude, latency, and velocity in healthy participants. MATERIALS AND METHODS: A prospective study was conduc...

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Autores principales: Chaudhari, Sweta Chetan, Mansukhani, Khushnuma Anil, Sharma, Alika, Balakrishnan, Lajita, Sreenivasan, Aarthika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470164/
https://www.ncbi.nlm.nih.gov/pubmed/28615897
http://dx.doi.org/10.4103/0972-2327.194313
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author Chaudhari, Sweta Chetan
Mansukhani, Khushnuma Anil
Sharma, Alika
Balakrishnan, Lajita
Sreenivasan, Aarthika
author_facet Chaudhari, Sweta Chetan
Mansukhani, Khushnuma Anil
Sharma, Alika
Balakrishnan, Lajita
Sreenivasan, Aarthika
author_sort Chaudhari, Sweta Chetan
collection PubMed
description BACKGROUND: Dorsal sural sensory nerve action potential (SNAP) could help diagnose early or subclinical peripheral neuropathy. OBJECTIVES: To establish reference data for dorsal sural SNAP amplitude, latency, and velocity in healthy participants. MATERIALS AND METHODS: A prospective study was conducted in 45 nerves from healthy participants between 18 and 90 years and stratified into three age groups (a = 18–40 years, b = 41–60 years, and c>60 years). StataCorp 12.2 statistical program was used for all statistical analyses. Mean-2 standard deviation was used to generate reference values for the lower limit of amplitude and velocity in each age group. ANOVA with Bonferroni correction was used for intergroup comparisons of amplitude and velocity. Regression analysis was used to compute an equation for the predicted amplitude with age, height, and weight as the covariates. RESULTS: The lower limit for amplitude (uv) in Groups a, b, and c was 2.57, 1.97, and 1.01, respectively. The lower limit for velocity (m/s) was 33.6, 32, and 22.8, respectively. Statistical significance was noted between the amplitudes of participants in Groups b and c (P = 0.039) and a and c (P = 0.001). Similarly, velocity was significantly different between Groups b and c (P = 0.04) and a and c (P = 0.008). Age was the covariate with maximum effect on the dorsal sural amplitude. Gender and side-to-side comparison did not show statistical significance for amplitude and velocity measurements. Linear regression analysis of the transformed amplitude gave the predictive equation as (y) =3.338 + age (−0.0167) + height in meters (−0.209) + weight (0.001). CONCLUSION: This study provides reference data for dorsal sural SNAP in Indian population stratified by age.
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spelling pubmed-54701642017-06-14 Dorsal Sural Sensory Nerve Action Potential: A Study for Reference Values Chaudhari, Sweta Chetan Mansukhani, Khushnuma Anil Sharma, Alika Balakrishnan, Lajita Sreenivasan, Aarthika Ann Indian Acad Neurol Original Article BACKGROUND: Dorsal sural sensory nerve action potential (SNAP) could help diagnose early or subclinical peripheral neuropathy. OBJECTIVES: To establish reference data for dorsal sural SNAP amplitude, latency, and velocity in healthy participants. MATERIALS AND METHODS: A prospective study was conducted in 45 nerves from healthy participants between 18 and 90 years and stratified into three age groups (a = 18–40 years, b = 41–60 years, and c>60 years). StataCorp 12.2 statistical program was used for all statistical analyses. Mean-2 standard deviation was used to generate reference values for the lower limit of amplitude and velocity in each age group. ANOVA with Bonferroni correction was used for intergroup comparisons of amplitude and velocity. Regression analysis was used to compute an equation for the predicted amplitude with age, height, and weight as the covariates. RESULTS: The lower limit for amplitude (uv) in Groups a, b, and c was 2.57, 1.97, and 1.01, respectively. The lower limit for velocity (m/s) was 33.6, 32, and 22.8, respectively. Statistical significance was noted between the amplitudes of participants in Groups b and c (P = 0.039) and a and c (P = 0.001). Similarly, velocity was significantly different between Groups b and c (P = 0.04) and a and c (P = 0.008). Age was the covariate with maximum effect on the dorsal sural amplitude. Gender and side-to-side comparison did not show statistical significance for amplitude and velocity measurements. Linear regression analysis of the transformed amplitude gave the predictive equation as (y) =3.338 + age (−0.0167) + height in meters (−0.209) + weight (0.001). CONCLUSION: This study provides reference data for dorsal sural SNAP in Indian population stratified by age. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5470164/ /pubmed/28615897 http://dx.doi.org/10.4103/0972-2327.194313 Text en Copyright: © 2006 - 2017 Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Chaudhari, Sweta Chetan
Mansukhani, Khushnuma Anil
Sharma, Alika
Balakrishnan, Lajita
Sreenivasan, Aarthika
Dorsal Sural Sensory Nerve Action Potential: A Study for Reference Values
title Dorsal Sural Sensory Nerve Action Potential: A Study for Reference Values
title_full Dorsal Sural Sensory Nerve Action Potential: A Study for Reference Values
title_fullStr Dorsal Sural Sensory Nerve Action Potential: A Study for Reference Values
title_full_unstemmed Dorsal Sural Sensory Nerve Action Potential: A Study for Reference Values
title_short Dorsal Sural Sensory Nerve Action Potential: A Study for Reference Values
title_sort dorsal sural sensory nerve action potential: a study for reference values
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470164/
https://www.ncbi.nlm.nih.gov/pubmed/28615897
http://dx.doi.org/10.4103/0972-2327.194313
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