Cargando…

Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study

BACKGROUND: To explore the associations between the Chinese famine exposure in early life and the dyslipidemia in adulthood. METHODS: We selected 2752 participants from the baseline survey of China Health and Retirement Longitudinal Study (CHARLS) 2011–2012 to evaluate the associations of early life...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhenghe, Li, Changwei, Yang, Zhongping, Ma, Jun, Zou, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470181/
https://www.ncbi.nlm.nih.gov/pubmed/28610568
http://dx.doi.org/10.1186/s12889-017-4421-6
_version_ 1783243725500055552
author Wang, Zhenghe
Li, Changwei
Yang, Zhongping
Ma, Jun
Zou, Zhiyong
author_facet Wang, Zhenghe
Li, Changwei
Yang, Zhongping
Ma, Jun
Zou, Zhiyong
author_sort Wang, Zhenghe
collection PubMed
description BACKGROUND: To explore the associations between the Chinese famine exposure in early life and the dyslipidemia in adulthood. METHODS: We selected 2752 participants from the baseline survey of China Health and Retirement Longitudinal Study (CHARLS) 2011–2012 to evaluate the associations of early life the Chinese famine exposure with risk of dyslipidemia in adulthood. Dyslipidemia was defined as TC (Total Cholesterol): HDL-C (High-Density Lipoprotein Cholesterol) ratio ≥ 5.0 or use cholesterol lowering drugs. Famine exposure cohorts were categorized by birthdates of participants. Binary logistics regression model was used to examine the associations of early-life famine exposure with the risk of dyslipidemia. RESULTS: The dyslipidemia prevalence of the non-exposed cohort, fetal stage-, infant stage-, and preschool stage-exposed cohorts in adulthood was 15.7%, 23.1%, 22.0%, and 18.6%, respectively. Early-life exposure to the Chinese famine significantly increased LDL cholesterol concentrations in adulthood after adjusted for age. The risks of dyslipidemia in fetal (OR = 1.58; 95% CI: 1.23–2.03; P < 0.001) and infant (OR = 1.52; 95% CI: 1.15–2.00; P = 0.003) stage-exposed cohorts were significantly higher than the non-exposed cohort after adjusted for gender and current family economic status. Following gender stratification, we found that fetal (OR = 1.80; 95% CI: 1.26–2.57; P = 0.001), infant (OR = 1.75; 95% CI: 1.17–2.62; P = 0.006), and preschool (OR = 1.63; 95% CI: 1.10–2.42; P = 0.015) -stage exposure to severe famine aggravated the risk of dyslipidemia in female adults. However, the similar association was not observed for male adults. CONCLUSIONS: Early-life exposure to severe Chinese famine could link with the higher dyslipidemia risk in female adulthood, but not in male adulthood. This gender-specific effect might be associated with the hypothesis that parents in China prefer boys to girls traditionally or survivors’ bias. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-017-4421-6) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-5470181
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-54701812017-06-19 Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study Wang, Zhenghe Li, Changwei Yang, Zhongping Ma, Jun Zou, Zhiyong BMC Public Health Research Article BACKGROUND: To explore the associations between the Chinese famine exposure in early life and the dyslipidemia in adulthood. METHODS: We selected 2752 participants from the baseline survey of China Health and Retirement Longitudinal Study (CHARLS) 2011–2012 to evaluate the associations of early life the Chinese famine exposure with risk of dyslipidemia in adulthood. Dyslipidemia was defined as TC (Total Cholesterol): HDL-C (High-Density Lipoprotein Cholesterol) ratio ≥ 5.0 or use cholesterol lowering drugs. Famine exposure cohorts were categorized by birthdates of participants. Binary logistics regression model was used to examine the associations of early-life famine exposure with the risk of dyslipidemia. RESULTS: The dyslipidemia prevalence of the non-exposed cohort, fetal stage-, infant stage-, and preschool stage-exposed cohorts in adulthood was 15.7%, 23.1%, 22.0%, and 18.6%, respectively. Early-life exposure to the Chinese famine significantly increased LDL cholesterol concentrations in adulthood after adjusted for age. The risks of dyslipidemia in fetal (OR = 1.58; 95% CI: 1.23–2.03; P < 0.001) and infant (OR = 1.52; 95% CI: 1.15–2.00; P = 0.003) stage-exposed cohorts were significantly higher than the non-exposed cohort after adjusted for gender and current family economic status. Following gender stratification, we found that fetal (OR = 1.80; 95% CI: 1.26–2.57; P = 0.001), infant (OR = 1.75; 95% CI: 1.17–2.62; P = 0.006), and preschool (OR = 1.63; 95% CI: 1.10–2.42; P = 0.015) -stage exposure to severe famine aggravated the risk of dyslipidemia in female adults. However, the similar association was not observed for male adults. CONCLUSIONS: Early-life exposure to severe Chinese famine could link with the higher dyslipidemia risk in female adulthood, but not in male adulthood. This gender-specific effect might be associated with the hypothesis that parents in China prefer boys to girls traditionally or survivors’ bias. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-017-4421-6) contains supplementary material, which is available to authorized users. BioMed Central 2017-06-14 /pmc/articles/PMC5470181/ /pubmed/28610568 http://dx.doi.org/10.1186/s12889-017-4421-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wang, Zhenghe
Li, Changwei
Yang, Zhongping
Ma, Jun
Zou, Zhiyong
Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study
title Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study
title_full Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study
title_fullStr Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study
title_full_unstemmed Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study
title_short Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study
title_sort fetal and infant exposure to severe chinese famine increases the risk of adult dyslipidemia: results from the china health and retirement longitudinal study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470181/
https://www.ncbi.nlm.nih.gov/pubmed/28610568
http://dx.doi.org/10.1186/s12889-017-4421-6
work_keys_str_mv AT wangzhenghe fetalandinfantexposuretoseverechinesefamineincreasestheriskofadultdyslipidemiaresultsfromthechinahealthandretirementlongitudinalstudy
AT lichangwei fetalandinfantexposuretoseverechinesefamineincreasestheriskofadultdyslipidemiaresultsfromthechinahealthandretirementlongitudinalstudy
AT yangzhongping fetalandinfantexposuretoseverechinesefamineincreasestheriskofadultdyslipidemiaresultsfromthechinahealthandretirementlongitudinalstudy
AT majun fetalandinfantexposuretoseverechinesefamineincreasestheriskofadultdyslipidemiaresultsfromthechinahealthandretirementlongitudinalstudy
AT zouzhiyong fetalandinfantexposuretoseverechinesefamineincreasestheriskofadultdyslipidemiaresultsfromthechinahealthandretirementlongitudinalstudy