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Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

BACKGROUND: Intracerebral hemorrhage (ICH) induces potently oxidative stress responses and inflammatory processes. Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure and can activate nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated antioxidant system, negatively regulate nuc...

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Detalles Bibliográficos
Autores principales:	Zeng, Jun, Chen, Yizhao, Ding, Rui, Feng, Liang, Fu, Zhenghao, Yang, Shuo, Deng, Xinqing, Xie, Zhichong, Zheng, Shizhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470182/ https://www.ncbi.nlm.nih.gov/pubmed/28610608 http://dx.doi.org/10.1186/s12974-017-0895-5

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