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Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis

BACKGROUND: Systemic sclerosis (SSc) is characterized by fibrosis of the skin and internal organs. Although the involvement of connective tissue growth factor (CTGF/CCN2) has been well-documented in SSc fibrosis, the therapeutic potential of targeting CTGF in SSc has not been fully investigated. Our...

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Detalles Bibliográficos
Autores principales:	Makino, Katsunari, Makino, Tomoko, Stawski, Lukasz, Lipson, Kenneth E., Leask, Andrew, Trojanowska, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470189/ https://www.ncbi.nlm.nih.gov/pubmed/28610597 http://dx.doi.org/10.1186/s13075-017-1356-3

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