Correspondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost

Through RNA-Seq analyses, we identified 137 genes that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor genes. These genes tended to cluster in GC-rich regions that have poor coverage in genome sequence databases. Hence, the occurrence of syntenic groups of v...

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Detalles Bibliográficos
Autores principales: Bornelöv, Susanne, Seroussi, Eyal, Yosefi, Sara, Pendavis, Ken, Burgess, Shane C., Grabherr, Manfred, Friedman-Einat, Miriam, Andersson, Leif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470226/
https://www.ncbi.nlm.nih.gov/pubmed/28615067
http://dx.doi.org/10.1186/s13059-017-1231-1
Descripción
Sumario:Through RNA-Seq analyses, we identified 137 genes that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor genes. These genes tended to cluster in GC-rich regions that have poor coverage in genome sequence databases. Hence, the occurrence of syntenic groups of vertebrate genes that have not been observed in Aves does not prove the evolutionary loss of such genes. Please see related Research article: http://dx.doi.org/10.1186/s13059-014-0565-1 and Please see response from Lovell et al: https://www.dx.doi.org/10.1186/s13059-017-1234-y ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13059-017-1231-1) contains supplementary material, which is available to authorized users.

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