Correspondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost

Through RNA-Seq analyses, we identified 137 genes that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor genes. These genes tended to cluster in GC-rich regions that have poor coverage in genome sequence databases. Hence, the occurrence of syntenic groups of v...

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Autores principales: Bornelöv, Susanne, Seroussi, Eyal, Yosefi, Sara, Pendavis, Ken, Burgess, Shane C., Grabherr, Manfred, Friedman-Einat, Miriam, Andersson, Leif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470226/
https://www.ncbi.nlm.nih.gov/pubmed/28615067
http://dx.doi.org/10.1186/s13059-017-1231-1
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author Bornelöv, Susanne
Seroussi, Eyal
Yosefi, Sara
Pendavis, Ken
Burgess, Shane C.
Grabherr, Manfred
Friedman-Einat, Miriam
Andersson, Leif
author_facet Bornelöv, Susanne
Seroussi, Eyal
Yosefi, Sara
Pendavis, Ken
Burgess, Shane C.
Grabherr, Manfred
Friedman-Einat, Miriam
Andersson, Leif
author_sort Bornelöv, Susanne
collection PubMed
description Through RNA-Seq analyses, we identified 137 genes that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor genes. These genes tended to cluster in GC-rich regions that have poor coverage in genome sequence databases. Hence, the occurrence of syntenic groups of vertebrate genes that have not been observed in Aves does not prove the evolutionary loss of such genes. Please see related Research article: http://dx.doi.org/10.1186/s13059-014-0565-1 and Please see response from Lovell et al: https://www.dx.doi.org/10.1186/s13059-017-1234-y ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13059-017-1231-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-54702262017-06-19 Correspondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost Bornelöv, Susanne Seroussi, Eyal Yosefi, Sara Pendavis, Ken Burgess, Shane C. Grabherr, Manfred Friedman-Einat, Miriam Andersson, Leif Genome Biol Correspondence Through RNA-Seq analyses, we identified 137 genes that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor genes. These genes tended to cluster in GC-rich regions that have poor coverage in genome sequence databases. Hence, the occurrence of syntenic groups of vertebrate genes that have not been observed in Aves does not prove the evolutionary loss of such genes. Please see related Research article: http://dx.doi.org/10.1186/s13059-014-0565-1 and Please see response from Lovell et al: https://www.dx.doi.org/10.1186/s13059-017-1234-y ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13059-017-1231-1) contains supplementary material, which is available to authorized users. BioMed Central 2017-06-14 /pmc/articles/PMC5470226/ /pubmed/28615067 http://dx.doi.org/10.1186/s13059-017-1231-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Correspondence
Bornelöv, Susanne
Seroussi, Eyal
Yosefi, Sara
Pendavis, Ken
Burgess, Shane C.
Grabherr, Manfred
Friedman-Einat, Miriam
Andersson, Leif
Correspondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost
title Correspondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost
title_full Correspondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost
title_fullStr Correspondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost
title_full_unstemmed Correspondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost
title_short Correspondence on Lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost
title_sort correspondence on lovell et al.: identification of chicken genes previously assumed to be evolutionarily lost
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470226/
https://www.ncbi.nlm.nih.gov/pubmed/28615067
http://dx.doi.org/10.1186/s13059-017-1231-1
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