Cellular function reinstitution of offspring red blood cells cloned from the sickle cell disease patient blood post CRISPR genome editing

BACKGROUND: Sickle cell disease (SCD) is a disorder of red blood cells (RBCs) expressing abnormal hemoglobin-S (HbS) due to genetic inheritance of homologous HbS gene. However, people with the sickle cell trait (SCT) carry a single allele of HbS and do not usually suffer from SCD symptoms, thus prov...

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Detalles Bibliográficos
Autores principales: Wen, Jianguo, Tao, Wenjing, Hao, Suyang, Zu, Youli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470227/
https://www.ncbi.nlm.nih.gov/pubmed/28610635
http://dx.doi.org/10.1186/s13045-017-0489-9

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