Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms

Amyotrophic lateral sclerosis, a devastating neurodegenerative disease, is characterized by the progressive loss of motor neurons and the accumulation of misfolded protein aggregates. The latter suggests impaired proteostasis may be a key factor in disease pathogenesis, though the underlying mechani...

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Detalles Bibliográficos
Autores principales: Madill, Martin, McDonagh, Katya, Ma, Jun, Vajda, Alice, McLoughlin, Paul, O’Brien, Timothy, Hardiman, Orla, Shen, Sanbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470320/
https://www.ncbi.nlm.nih.gov/pubmed/28610619
http://dx.doi.org/10.1186/s13041-017-0300-4

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