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Mechanics Based Tomography: A Preliminary Feasibility Study

We present a non-destructive approach to sense inclusion objects embedded in a solid medium remotely from force sensors applied to the medium and boundary displacements that could be measured via a digital image correlation system using a set of cameras. We provide a rationale and strategy to unique...

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Autores principales: Mei, Yue, Wang, Sicheng, Shen, Xin, Rabke, Stephen, Goenezen, Sevan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470465/
https://www.ncbi.nlm.nih.gov/pubmed/28486429
http://dx.doi.org/10.3390/s17051075
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author Mei, Yue
Wang, Sicheng
Shen, Xin
Rabke, Stephen
Goenezen, Sevan
author_facet Mei, Yue
Wang, Sicheng
Shen, Xin
Rabke, Stephen
Goenezen, Sevan
author_sort Mei, Yue
collection PubMed
description We present a non-destructive approach to sense inclusion objects embedded in a solid medium remotely from force sensors applied to the medium and boundary displacements that could be measured via a digital image correlation system using a set of cameras. We provide a rationale and strategy to uniquely identify the heterogeneous sample composition based on stiffness (here, shear modulus) maps. The feasibility of this inversion scheme is tested with simulated experiments that could have clinical relevance in diagnostic imaging (e.g., tumor detection) or could be applied to engineering materials. No assumptions are made on the shape or stiffness quantity of the inclusions. We observe that the novel inversion method using solely boundary displacements and force measurements performs well in recovering the heterogeneous material/tissue composition that consists of one and two stiff inclusions embedded in a softer background material. Furthermore, the target shear modulus value for the stiffer inclusion region is underestimated and the inclusion size is overestimated when incomplete boundary displacements on some part of the boundary are utilized. For displacements measured on the entire boundary, the shear modulus reconstruction improves significantly. Additionally, we observe that with increasing number of displacement data sets utilized in solving the inverse problem, the quality of the mapped shear moduli improves. We also analyze the sensitivity of the shear modulus maps on the noise level varied between 0.1% and 5% white Gaussian noise in the boundary displacements, force and corresponding displacement indentation. Finally, a sensitivity analysis of the recovered shear moduli to the depth, stiffness and the shape of the stiff inclusion is performed. We conclude that this approach has potential as a novel imaging modality and refer to it as Mechanics Based Tomography (MBT).
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spelling pubmed-54704652017-06-16 Mechanics Based Tomography: A Preliminary Feasibility Study Mei, Yue Wang, Sicheng Shen, Xin Rabke, Stephen Goenezen, Sevan Sensors (Basel) Article We present a non-destructive approach to sense inclusion objects embedded in a solid medium remotely from force sensors applied to the medium and boundary displacements that could be measured via a digital image correlation system using a set of cameras. We provide a rationale and strategy to uniquely identify the heterogeneous sample composition based on stiffness (here, shear modulus) maps. The feasibility of this inversion scheme is tested with simulated experiments that could have clinical relevance in diagnostic imaging (e.g., tumor detection) or could be applied to engineering materials. No assumptions are made on the shape or stiffness quantity of the inclusions. We observe that the novel inversion method using solely boundary displacements and force measurements performs well in recovering the heterogeneous material/tissue composition that consists of one and two stiff inclusions embedded in a softer background material. Furthermore, the target shear modulus value for the stiffer inclusion region is underestimated and the inclusion size is overestimated when incomplete boundary displacements on some part of the boundary are utilized. For displacements measured on the entire boundary, the shear modulus reconstruction improves significantly. Additionally, we observe that with increasing number of displacement data sets utilized in solving the inverse problem, the quality of the mapped shear moduli improves. We also analyze the sensitivity of the shear modulus maps on the noise level varied between 0.1% and 5% white Gaussian noise in the boundary displacements, force and corresponding displacement indentation. Finally, a sensitivity analysis of the recovered shear moduli to the depth, stiffness and the shape of the stiff inclusion is performed. We conclude that this approach has potential as a novel imaging modality and refer to it as Mechanics Based Tomography (MBT). MDPI 2017-05-09 /pmc/articles/PMC5470465/ /pubmed/28486429 http://dx.doi.org/10.3390/s17051075 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mei, Yue
Wang, Sicheng
Shen, Xin
Rabke, Stephen
Goenezen, Sevan
Mechanics Based Tomography: A Preliminary Feasibility Study
title Mechanics Based Tomography: A Preliminary Feasibility Study
title_full Mechanics Based Tomography: A Preliminary Feasibility Study
title_fullStr Mechanics Based Tomography: A Preliminary Feasibility Study
title_full_unstemmed Mechanics Based Tomography: A Preliminary Feasibility Study
title_short Mechanics Based Tomography: A Preliminary Feasibility Study
title_sort mechanics based tomography: a preliminary feasibility study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470465/
https://www.ncbi.nlm.nih.gov/pubmed/28486429
http://dx.doi.org/10.3390/s17051075
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AT goenezensevan mechanicsbasedtomographyapreliminaryfeasibilitystudy