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An innovative biologic system for photon-powered myocardium in the ischemic heart
Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470824/ https://www.ncbi.nlm.nih.gov/pubmed/28630913 http://dx.doi.org/10.1126/sciadv.1603078 |
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author | Cohen, Jeffrey E. Goldstone, Andrew B. Paulsen, Michael J. Shudo, Yasuhiro Steele, Amanda N. Edwards, Bryan B. Patel, Jay B. MacArthur, John W. Hopkins, Michael S. Burnett, Casey E. Jaatinen, Kevin J. Thakore, Akshara D. Farry, Justin M. Truong, Vi N. Bourdillon, Alexandra T. Stapleton, Lyndsay M. Eskandari, Anahita Fairman, Alexander S. Hiesinger, William Esipova, Tatiana V. Patrick, William L. Ji, Keven Shizuru, Judith A. Woo, Y. Joseph |
author_facet | Cohen, Jeffrey E. Goldstone, Andrew B. Paulsen, Michael J. Shudo, Yasuhiro Steele, Amanda N. Edwards, Bryan B. Patel, Jay B. MacArthur, John W. Hopkins, Michael S. Burnett, Casey E. Jaatinen, Kevin J. Thakore, Akshara D. Farry, Justin M. Truong, Vi N. Bourdillon, Alexandra T. Stapleton, Lyndsay M. Eskandari, Anahita Fairman, Alexander S. Hiesinger, William Esipova, Tatiana V. Patrick, William L. Ji, Keven Shizuru, Judith A. Woo, Y. Joseph |
author_sort | Cohen, Jeffrey E. |
collection | PubMed |
description | Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual microvascular perfusion deficit that remains after revascularization. We present a novel system that rescues the myocardium from acute ischemia, using photosynthesis through intramyocardial delivery of the cyanobacterium Synechococcus elongatus. By using light rather than blood flow as a source of energy, photosynthetic therapy increases tissue oxygenation, maintains myocardial metabolism, and yields durable improvements in cardiac function during and after induction of ischemia. By circumventing blood flow entirely to provide tissue with oxygen and nutrients, this system has the potential to create a paradigm shift in the way ischemic heart disease is treated. |
format | Online Article Text |
id | pubmed-5470824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54708242017-06-19 An innovative biologic system for photon-powered myocardium in the ischemic heart Cohen, Jeffrey E. Goldstone, Andrew B. Paulsen, Michael J. Shudo, Yasuhiro Steele, Amanda N. Edwards, Bryan B. Patel, Jay B. MacArthur, John W. Hopkins, Michael S. Burnett, Casey E. Jaatinen, Kevin J. Thakore, Akshara D. Farry, Justin M. Truong, Vi N. Bourdillon, Alexandra T. Stapleton, Lyndsay M. Eskandari, Anahita Fairman, Alexander S. Hiesinger, William Esipova, Tatiana V. Patrick, William L. Ji, Keven Shizuru, Judith A. Woo, Y. Joseph Sci Adv Research Articles Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual microvascular perfusion deficit that remains after revascularization. We present a novel system that rescues the myocardium from acute ischemia, using photosynthesis through intramyocardial delivery of the cyanobacterium Synechococcus elongatus. By using light rather than blood flow as a source of energy, photosynthetic therapy increases tissue oxygenation, maintains myocardial metabolism, and yields durable improvements in cardiac function during and after induction of ischemia. By circumventing blood flow entirely to provide tissue with oxygen and nutrients, this system has the potential to create a paradigm shift in the way ischemic heart disease is treated. American Association for the Advancement of Science 2017-06-14 /pmc/articles/PMC5470824/ /pubmed/28630913 http://dx.doi.org/10.1126/sciadv.1603078 Text en Copyright © 2017, The Authors http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Cohen, Jeffrey E. Goldstone, Andrew B. Paulsen, Michael J. Shudo, Yasuhiro Steele, Amanda N. Edwards, Bryan B. Patel, Jay B. MacArthur, John W. Hopkins, Michael S. Burnett, Casey E. Jaatinen, Kevin J. Thakore, Akshara D. Farry, Justin M. Truong, Vi N. Bourdillon, Alexandra T. Stapleton, Lyndsay M. Eskandari, Anahita Fairman, Alexander S. Hiesinger, William Esipova, Tatiana V. Patrick, William L. Ji, Keven Shizuru, Judith A. Woo, Y. Joseph An innovative biologic system for photon-powered myocardium in the ischemic heart |
title | An innovative biologic system for photon-powered myocardium in the ischemic heart |
title_full | An innovative biologic system for photon-powered myocardium in the ischemic heart |
title_fullStr | An innovative biologic system for photon-powered myocardium in the ischemic heart |
title_full_unstemmed | An innovative biologic system for photon-powered myocardium in the ischemic heart |
title_short | An innovative biologic system for photon-powered myocardium in the ischemic heart |
title_sort | innovative biologic system for photon-powered myocardium in the ischemic heart |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470824/ https://www.ncbi.nlm.nih.gov/pubmed/28630913 http://dx.doi.org/10.1126/sciadv.1603078 |
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