A Computational Methodology to Overcome the Challenges Associated With the Search for Specific Enzyme Targets to Develop Drugs Against Leishmania major

We present an approach for detecting enzymes that are specific of Leishmania major compared with Homo sapiens and provide targets that may assist research in drug development. This approach is based on traditional techniques of sequence homology comparison by similarity search and Markov modeling; i...

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Detalles Bibliográficos
Autores principales: Catharina, Larissa, Lima, Carlyle Ribeiro, Franca, Alexander, Guimarães, Ana Carolina Ramos, Alves-Ferreira, Marcelo, Tuffery, Pierre, Derreumaux, Philippe, Carels, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470852/
https://www.ncbi.nlm.nih.gov/pubmed/28638238
http://dx.doi.org/10.1177/1177932217712471

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