Foxo3a-dependent Bim transcription protects mice from a high fat diet via inhibition of activation of the NLRP3 inflammasome by facilitating autophagy flux in Kupffer cells

BACKGROUND: The role of Foxo3a in the regulation of autophagy flux and activation of the NLRP3 inflammasome in KCs suffering from HFD conditions is unknown. RESULTS: Up-regulation of Foxo3a restored autophagy flux and dampened the activation of the NLRP3 inflammasome in KCs stimulated with PA and LP...

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Detalles Bibliográficos
Autores principales: Liu, Yan, Zhang, Wenfeng, Wu, Xiaoling, Gong, Jian-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470965/
https://www.ncbi.nlm.nih.gov/pubmed/28427239
http://dx.doi.org/10.18632/oncotarget.15946

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