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(18)F-deoxyglucose positron emission tomography/computed tomography to predict local failure in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) patients are at risk for local failure (LF) following treatment. Predicting tumor regions at high risk for local failure before radiotherapy may increase treatment efficacy by permitting an escalated radiation dose specifically to those regions critical for...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470985/ https://www.ncbi.nlm.nih.gov/pubmed/28404900 http://dx.doi.org/10.18632/oncotarget.15606 |
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author | Fan, Bingjie Fan, Pingping Kong, Li Sun, Xindong Zhao, Shuqiang Sun, Xiaorong Fu, Zheng Zheng, Jinsong Ma, Li Wang, Shijiang Hu, Man Yu, Jinming |
author_facet | Fan, Bingjie Fan, Pingping Kong, Li Sun, Xindong Zhao, Shuqiang Sun, Xiaorong Fu, Zheng Zheng, Jinsong Ma, Li Wang, Shijiang Hu, Man Yu, Jinming |
author_sort | Fan, Bingjie |
collection | PubMed |
description | Esophageal squamous cell carcinoma (ESCC) patients are at risk for local failure (LF) following treatment. Predicting tumor regions at high risk for local failure before radiotherapy may increase treatment efficacy by permitting an escalated radiation dose specifically to those regions critical for tumor control. Forty-one patients with non-resectable locally advanced ESCC underwent (18)F-deoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging before concurrent chemoradiotherapy (CCRT). After CCRT, a second (failure) FDG PET/CT was performed in cases of relapse. Failure FDG PET/CT scans were fused to pre-treatment scans to identify tumor regions at high risk for LF. Within a median follow-up time of 26 months, 20 patients (48.8%) had LF. In 19 patients, the failure occurred within a pre-treatment high FDG uptake region; the failure occurred outside these regions in only one patient. Pre-treatment metabolic tumor volume (MTV) was independently associated with LF (P<0.001, HR 1.128, 95% CI: 1.061–1.198). LF was more likely in patients with MTVs ≥27 cm(3). In initial PET/CT images, when 50% maximum standardized uptake value (SUV(max)) was used as the threshold, delineated subvolumes overlapped LF regions. These results confirm that LF occurs most commonly within pre-treatment high FDG uptake regions. |
format | Online Article Text |
id | pubmed-5470985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54709852017-06-27 (18)F-deoxyglucose positron emission tomography/computed tomography to predict local failure in esophageal squamous cell carcinoma Fan, Bingjie Fan, Pingping Kong, Li Sun, Xindong Zhao, Shuqiang Sun, Xiaorong Fu, Zheng Zheng, Jinsong Ma, Li Wang, Shijiang Hu, Man Yu, Jinming Oncotarget Research Paper Esophageal squamous cell carcinoma (ESCC) patients are at risk for local failure (LF) following treatment. Predicting tumor regions at high risk for local failure before radiotherapy may increase treatment efficacy by permitting an escalated radiation dose specifically to those regions critical for tumor control. Forty-one patients with non-resectable locally advanced ESCC underwent (18)F-deoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging before concurrent chemoradiotherapy (CCRT). After CCRT, a second (failure) FDG PET/CT was performed in cases of relapse. Failure FDG PET/CT scans were fused to pre-treatment scans to identify tumor regions at high risk for LF. Within a median follow-up time of 26 months, 20 patients (48.8%) had LF. In 19 patients, the failure occurred within a pre-treatment high FDG uptake region; the failure occurred outside these regions in only one patient. Pre-treatment metabolic tumor volume (MTV) was independently associated with LF (P<0.001, HR 1.128, 95% CI: 1.061–1.198). LF was more likely in patients with MTVs ≥27 cm(3). In initial PET/CT images, when 50% maximum standardized uptake value (SUV(max)) was used as the threshold, delineated subvolumes overlapped LF regions. These results confirm that LF occurs most commonly within pre-treatment high FDG uptake regions. Impact Journals LLC 2017-02-22 /pmc/articles/PMC5470985/ /pubmed/28404900 http://dx.doi.org/10.18632/oncotarget.15606 Text en Copyright: © 2017 Fan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Fan, Bingjie Fan, Pingping Kong, Li Sun, Xindong Zhao, Shuqiang Sun, Xiaorong Fu, Zheng Zheng, Jinsong Ma, Li Wang, Shijiang Hu, Man Yu, Jinming (18)F-deoxyglucose positron emission tomography/computed tomography to predict local failure in esophageal squamous cell carcinoma |
title | (18)F-deoxyglucose positron emission tomography/computed tomography to predict local failure in esophageal squamous cell carcinoma |
title_full | (18)F-deoxyglucose positron emission tomography/computed tomography to predict local failure in esophageal squamous cell carcinoma |
title_fullStr | (18)F-deoxyglucose positron emission tomography/computed tomography to predict local failure in esophageal squamous cell carcinoma |
title_full_unstemmed | (18)F-deoxyglucose positron emission tomography/computed tomography to predict local failure in esophageal squamous cell carcinoma |
title_short | (18)F-deoxyglucose positron emission tomography/computed tomography to predict local failure in esophageal squamous cell carcinoma |
title_sort | (18)f-deoxyglucose positron emission tomography/computed tomography to predict local failure in esophageal squamous cell carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470985/ https://www.ncbi.nlm.nih.gov/pubmed/28404900 http://dx.doi.org/10.18632/oncotarget.15606 |
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