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Platelet distribution width correlates with prognosis of non-small cell lung cancer

Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used platelet parameters from routine blood test. The aim of the present study was to investigate the correlation between platelet indices and progno...

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Autores principales: Cui, Ming-ming, Li, Na, Liu, Xing, Yun, Zhi-yuan, Niu, Ye, Zhang, Yong, Gao, Boning, Liu, Tiemin, Wang, Rui-tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471191/
https://www.ncbi.nlm.nih.gov/pubmed/28615714
http://dx.doi.org/10.1038/s41598-017-03772-z
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author Cui, Ming-ming
Li, Na
Liu, Xing
Yun, Zhi-yuan
Niu, Ye
Zhang, Yong
Gao, Boning
Liu, Tiemin
Wang, Rui-tao
author_facet Cui, Ming-ming
Li, Na
Liu, Xing
Yun, Zhi-yuan
Niu, Ye
Zhang, Yong
Gao, Boning
Liu, Tiemin
Wang, Rui-tao
author_sort Cui, Ming-ming
collection PubMed
description Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used platelet parameters from routine blood test. The aim of the present study was to investigate the correlation between platelet indices and prognosis in patients with non-small cell lung cancer (NSCLC). A total of 270 patients who were diagnosed with NSCLC between January 2009 and December 2009 were retrospectively analyzed. Patients’ characteristics and hematologic tests data at initial diagnosis were collected. The overall survival rate was estimated using Kaplan-Meier method. The prognostic analysis was carried out with univariate and multivariate Cox regressions model. Reduced PDW was significantly correlated with T stage, N stage, TNM stage, and histological type of the disease. Moreover, survival analysis showed that the overall survival of patients with PDW ≥ 16.3% was significantly longer than that of those with PDW < 16.3% (P < 0.001). In multivariate Cox regression model, age, sex, TNM stage, and PDW were identified as independent prognostic factors for overall survival (for PDW, P < 0.001). In conclusion, reduced PDW is an unfavorable predictive factor of NSCLC patient survival. Further studies are warranted.
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spelling pubmed-54711912017-06-19 Platelet distribution width correlates with prognosis of non-small cell lung cancer Cui, Ming-ming Li, Na Liu, Xing Yun, Zhi-yuan Niu, Ye Zhang, Yong Gao, Boning Liu, Tiemin Wang, Rui-tao Sci Rep Article Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used platelet parameters from routine blood test. The aim of the present study was to investigate the correlation between platelet indices and prognosis in patients with non-small cell lung cancer (NSCLC). A total of 270 patients who were diagnosed with NSCLC between January 2009 and December 2009 were retrospectively analyzed. Patients’ characteristics and hematologic tests data at initial diagnosis were collected. The overall survival rate was estimated using Kaplan-Meier method. The prognostic analysis was carried out with univariate and multivariate Cox regressions model. Reduced PDW was significantly correlated with T stage, N stage, TNM stage, and histological type of the disease. Moreover, survival analysis showed that the overall survival of patients with PDW ≥ 16.3% was significantly longer than that of those with PDW < 16.3% (P < 0.001). In multivariate Cox regression model, age, sex, TNM stage, and PDW were identified as independent prognostic factors for overall survival (for PDW, P < 0.001). In conclusion, reduced PDW is an unfavorable predictive factor of NSCLC patient survival. Further studies are warranted. Nature Publishing Group UK 2017-06-14 /pmc/articles/PMC5471191/ /pubmed/28615714 http://dx.doi.org/10.1038/s41598-017-03772-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Cui, Ming-ming
Li, Na
Liu, Xing
Yun, Zhi-yuan
Niu, Ye
Zhang, Yong
Gao, Boning
Liu, Tiemin
Wang, Rui-tao
Platelet distribution width correlates with prognosis of non-small cell lung cancer
title Platelet distribution width correlates with prognosis of non-small cell lung cancer
title_full Platelet distribution width correlates with prognosis of non-small cell lung cancer
title_fullStr Platelet distribution width correlates with prognosis of non-small cell lung cancer
title_full_unstemmed Platelet distribution width correlates with prognosis of non-small cell lung cancer
title_short Platelet distribution width correlates with prognosis of non-small cell lung cancer
title_sort platelet distribution width correlates with prognosis of non-small cell lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471191/
https://www.ncbi.nlm.nih.gov/pubmed/28615714
http://dx.doi.org/10.1038/s41598-017-03772-z
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