Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development

Mice lacking secreted IgM (sIgM (−/−)) antibodies display abnormal splenic B cell development, which results in increased marginal zone and decreased follicular B cell numbers. However, the mechanism by which sIgM exhibit this effect is unknown. Here, we demonstrate that B cells in sIgM (−/−) mice d...

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Detalles Bibliográficos
Autores principales: Tsiantoulas, Dimitrios, Kiss, Mate, Bartolini-Gritti, Barbara, Bergthaler, Andreas, Mallat, Ziad, Jumaa, Hassan, Binder, Christoph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471202/
https://www.ncbi.nlm.nih.gov/pubmed/28615655
http://dx.doi.org/10.1038/s41598-017-03688-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471202/
https://www.ncbi.nlm.nih.gov/pubmed/28615655
http://dx.doi.org/10.1038/s41598-017-03688-8

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