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Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development
Mice lacking secreted IgM (sIgM (−/−)) antibodies display abnormal splenic B cell development, which results in increased marginal zone and decreased follicular B cell numbers. However, the mechanism by which sIgM exhibit this effect is unknown. Here, we demonstrate that B cells in sIgM (−/−) mice d...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471202/ https://www.ncbi.nlm.nih.gov/pubmed/28615655 http://dx.doi.org/10.1038/s41598-017-03688-8 |