Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

Therapy for nonalcoholic steatohepatitis (NASH) is limited. Andrographolide (ANDRO), a botanical compound, has a potent anti-inflammatory activity due to its ability to inhibit NF-κB. ANDRO has been also shown to inhibit the NLRP3 inflammasome, a relevant pathway in NASH. Our aim was to evaluate the...

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Detalles Bibliográficos
Autores principales: Cabrera, Daniel, Wree, Alexander, Povero, Davide, Solís, Nancy, Hernandez, Alejandra, Pizarro, Margarita, Moshage, Han, Torres, Javiera, Feldstein, Ariel E., Cabello-Verrugio, Claudio, Brandan, Enrique, Barrera, Francisco, Arab, Juan Pablo, Arrese, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471224/
https://www.ncbi.nlm.nih.gov/pubmed/28615649
http://dx.doi.org/10.1038/s41598-017-03675-z

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