Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment

In mucopolysaccharidoses (MPS), glycosaminoglycans (GAG) accumulate in tissues. In MPS II, approximately two-thirds of patients are cognitively impaired. We investigated levels of GAG in cerebrospinal fluid (CSF) in different populations from four clinical studies (including NCT00920647 and NCT01449...

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Autores principales: Hendriksz, Christian J., Muenzer, Joseph, Vanderver, Adeline, Davis, Jonathan M., Burton, Barbara K., Mendelsohn, Nancy J., Wang, Nan, Pan, Luying, Pano, Arian, Barbier, Ann J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471392/
https://www.ncbi.nlm.nih.gov/pubmed/28649553
http://dx.doi.org/10.1016/j.ymgmr.2015.11.001
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author Hendriksz, Christian J.
Muenzer, Joseph
Vanderver, Adeline
Davis, Jonathan M.
Burton, Barbara K.
Mendelsohn, Nancy J.
Wang, Nan
Pan, Luying
Pano, Arian
Barbier, Ann J.
author_facet Hendriksz, Christian J.
Muenzer, Joseph
Vanderver, Adeline
Davis, Jonathan M.
Burton, Barbara K.
Mendelsohn, Nancy J.
Wang, Nan
Pan, Luying
Pano, Arian
Barbier, Ann J.
author_sort Hendriksz, Christian J.
collection PubMed
description In mucopolysaccharidoses (MPS), glycosaminoglycans (GAG) accumulate in tissues. In MPS II, approximately two-thirds of patients are cognitively impaired. We investigated levels of GAG in cerebrospinal fluid (CSF) in different populations from four clinical studies (including NCT00920647 and NCT01449240). Data indicate that MPS II patients with cognitive impairment have elevated levels of CSF GAG, whereas those with the attenuated phenotype typically have levels falling between those of the cognitively affected patients and healthy controls.
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spelling pubmed-54713922017-06-23 Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment Hendriksz, Christian J. Muenzer, Joseph Vanderver, Adeline Davis, Jonathan M. Burton, Barbara K. Mendelsohn, Nancy J. Wang, Nan Pan, Luying Pano, Arian Barbier, Ann J. Mol Genet Metab Rep Short Communication In mucopolysaccharidoses (MPS), glycosaminoglycans (GAG) accumulate in tissues. In MPS II, approximately two-thirds of patients are cognitively impaired. We investigated levels of GAG in cerebrospinal fluid (CSF) in different populations from four clinical studies (including NCT00920647 and NCT01449240). Data indicate that MPS II patients with cognitive impairment have elevated levels of CSF GAG, whereas those with the attenuated phenotype typically have levels falling between those of the cognitively affected patients and healthy controls. Elsevier 2015-11-09 /pmc/articles/PMC5471392/ /pubmed/28649553 http://dx.doi.org/10.1016/j.ymgmr.2015.11.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Short Communication
Hendriksz, Christian J.
Muenzer, Joseph
Vanderver, Adeline
Davis, Jonathan M.
Burton, Barbara K.
Mendelsohn, Nancy J.
Wang, Nan
Pan, Luying
Pano, Arian
Barbier, Ann J.
Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment
title Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment
title_full Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment
title_fullStr Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment
title_full_unstemmed Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment
title_short Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment
title_sort levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and hunter syndrome patients with and without cognitive impairment
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471392/
https://www.ncbi.nlm.nih.gov/pubmed/28649553
http://dx.doi.org/10.1016/j.ymgmr.2015.11.001
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